摘要
目的:探讨幽门螺杆菌(helicobacter pylori,Hp)感染的胃癌及癌前病变患者环氧化酶2(COX-2)的表达及Hp与COX-2协同作用与胃癌发生的关系。方法:应用免疫组化方法测定62例COX-2表达情况,选择20例胃癌、30例萎缩性胃炎(其中包括18例异型增生及12例肠上皮化生)、12例浅表性胃炎,用快速尿素酶法和HE染色检测Hp感染情况。结果:胃癌组Hp感染12例(12/20,60%)。COX-2在异型增生组织中的阳性表达率与胃癌、肠上皮化生相比差异无统计学意义(P>0.05)。Hp阳性组肠上皮化生、异型增生组织及胃癌中COX-2的阳性表达率显著高于Hp阴性组(P<0.05)。结论:Hp菌株感染可上调胃癌组织中COX-2的表达,Hp感染和COX-2过度表达在胃癌的发生中起重要作用。
Objective: To investigate the possible role of Helicobacter pylori (Hp) infection in the development of gastric cancer. Method: Immunohistochemical staining was used to detect the expression of COX-2 in 12 cases of chronic superficial gastritis, 30 cases of chronic atrophic gastritis (including 12 cases of intestinal meta- plasia and 18 cases of dysplasia )and 20 cases of gastric cancer. Hp was assessed by using rapid urease staining test combined with HE staining test. Results: The infection of HP in gastric carcinoma was found in 12 cases (12/20, 60% ), and there was no significant difference in the positive rate of COX-2 between dysplasia and gastric cancer or intestinal metaplasia( P 〉 0.05), and their expression level were intensive in Hp positive patients when compared with Hp negative patients in precancerous lesions ( P 〈 0.05). Conclusion: COX-2 gene expression is accelerated in early gastric cancer. Hp might act as a tumor promoter in the genesis of gastric carcinoma.
出处
《山东大学学报(医学版)》
CAS
北大核心
2006年第7期703-705,709,共4页
Journal of Shandong University:Health Sciences
关键词
螺杆菌
幽门
胃肿瘤
癌前病变
环氧合酶
Helicobacter pylori (Hp)
Stomach neoplasms
Precancerous lesions
Cyclooxygenase