虎掌南星、白附片抗氧化作用的实验研究

Experimental Studies on the Anti-Oxidation Action of the Tuber of Pedate Pinellia (Pinellia pedatisecta )and the Root of Common Monkshood(Aconitum carmichaeli)

本实验对常用的天南星科药材虎掌南星、姜半夏、水半夏和毛莨科药材白附片、九节菖蒲的醇提物进行抗脂质过氧化作用的研究，观察了药物对亚油酸的空气氧化的抑制作用，发现这几种药材具有较强的抗氧化性能，尤以虎掌南星和白附片更为显著。药理实验显示这两种药材能显著增强小鼠血中谷胱甘肽过氧化物酶和过氧化氢酶的活性，与对照组比较，分别P＜0．01和P＜0．05，研究表明虎掌南星和白附片是天然抗氧化剂，抗氧化作用可能是这些中药功效的现代药理学基础之一。

Anti-lipid peroxidation actions of alcoholic extracts of common Araceae medicinal materials(Pinellia pedatisecta, Typhonium flaglliforme, Pinellia ternata) and Ranunculaceae medicinal materials (Aconitum carmichaeli,Anemone altaica)were studied. Inhibition of air-oxidation of linoleic acid by these drugs were observed in the experiments. It was found that Araceae and Ranunculaceae crude drugs showed good antioxidative effects,especially with P. pedatisecta and A. carmichaeli which showed more remarkable inhibition. Pharmacological studies showed that GSH-Px activity in the whole blood of rats fed with these two crude drugs and CAT activity in red cells of the rats were significantly higher than that in control group(P<0. 01 and P<0. 05 respectively). The results showed that P. pedatisecta and A. carmichaeli are natural antioxidants.