低氧诱导的蛋白表达研究进展

The Progress of Protein Expression induced by Hypoxia

细胞对缺氧的反应以一定数量的基因表达改变为特征。本文综述先前及近期关于慢性持续低氧及间断缺氧情况下蛋白质表达改变的研究。一系列结果显示,低氧影响能量代谢等多个领域相关蛋白的状态和水平。这些研究结果提供了进一步分析蛋白功能和定义细胞对低氧反应的机制的可能,并在临床上更有效地控制缺氧引起的后果。

The cellular responses to hypoxia are characterized by alterations in the expression of a number of genes. This article reviews previous and recent studies that have examined the changes in the expression of proteins in response to chronic sustained and intermittent hypoxia. Results showed that hypoxia affects the level and the state of proteins related to many domain about energy metabolism. This research results provide the possibility for the further ananlysis of protein function and definition of the mechanism about the reaction of cell to hypoxia, which then can play an effective role in control the consequence resulting from hypoxia.