支气管哮喘患者血浆生物活性肽含量变化及其临床意义

Content change of bioactive peptide in blood of the patients with bronchial asthma

作者采用放免分析法测定了１４例支气管哮喘发作期患者血浆中神经肽，神经肽Ｐ物质、血管活性肠肽、内皮素一１含量，并以１５例正常健康人做对照。发现支气管哮喘（以下简称哮喘）患者血浆中神经肽Ｐ物质、内皮素一１含量较正常健康人明显增高，血浆中血管活性肠肽含量较正常健康人明显降低。

ln this study,substance P(SP),vasoactive intestinal peptide(VIP )and endothelin(ET一1)in blcod in l 4 paients with bronchial asthma during acute stage were determined and 15heaIthy persons were used as a control group.The resuIt showed that SP and VIP in blood of the pa-tients were much higher than those of heaIthy people and that VIP in blood of the patiects was muchlower than that of heaIthy people. We further studied their parts in pathogenic mechanism of asthma.