急性心肌梗死治疗前后甲状腺激素变化与心功能的关系

Relationship between Change of Thyroid Hormone and Cardiac Function in Patients with Acute Myocardial Infarction Before and After Treatment

目的探讨也门亚丁地区急性心肌梗死治疗前后甲状腺激素变化与心功能的关系。方法42例急性心肌梗死(AMI)患者在入院后第2天、第4周末和18例健康对照组采用放射免疫法(RIA)测定tri-iodothyronine(T3)、thy-roxine(T4)、促甲状腺激素(TSH)。结果AMI治疗前,T3、T4均有不同程度下降,心功能Ⅰ级与心功能Ⅱ级以上者之间差异无显著性,但与健康对照组比较,差异有显著性;AMI治疗后,心功能恢复为Ⅰ级者,T3、T4恢复正常,与对照组比较差异无显著性;心功能Ⅱ级以上者,T3、T4持续下降,与对照组比较差异有显著性。治疗前后TSH正常,对照组与异常组TSH相互比较差异无显著性。结论监测T3、T4、对判断AMI患者心功能损害程度有一定的临床价值。

Objective To explore relationship between change of thyroid hormone and cardiac function in patients with acute myocardial infarction before treatment and after treatment. Methods 42 patients with acute myocardial infarction （AMI） and 18 healthy persons were enrolled. Tri-iodothyronine （T3）, thyroxine （T4）, thyroid stimulating hormone （TSH） of patients and controls were detected at the second day and the fourth weekend of admission. Results T3, T4 of the patients with AMI before treatment were decreased. There were no significant changes between cardiac function class Ⅰ and class 11 or more. But the difference between patients and healthy controls was significantly; after treatment, cardiac function of patients with AMI recovered to class, their T3, T4 were normal. If cardiac function of patients became class Ⅱ or more, their T3,T4 were decreased. There were significant changes compared with healthy controls. TSH of patients with AMI before and after treatment was normal. Conclusions The levels of T3, T4 is help to the judgment of cardiac function in patients with AMI.