胃疡安与叶酸治疗慢性萎缩性胃炎疗效观察

Treatment Effect Comparison of Weiyangan and Folic acid on Chronic Atrophic Gastritis.

目的 比较胃疡安与叶酸治疗慢性萎缩性胃炎（CAG）的疗效。方法 CAG121例随机分为胃疡安组（61例）及叶酸组（60例），胃疡安组口服胃疡安胶囊4g，3次／d，叶酸组口服叶酸10mg，3次／d，疗程均为6个月。结果 两组胃粘膜活检萎缩好转率无显著差异（P〉0.05），胃疡安组临床症状、胃粘膜慢性炎症及肠化的好转率优于叶酸组（P〈0．05）。结论 胃疡安是治疗CAG的有效药物，尤其对胃粘膜肠化有较好的逆转作用。

Objective To compare the treatment effect of folic acid （FA） and Weiyangan （WYA） on chronic atrophic gastritis, Methods One hundred and twenty one CAG cases were randomly divided into two groups： WYA group （61 cases） and FA group （60 cases）, and were treated with WYA or FA for 6 months respectively. Results To gastric mucus, anti-atrophy effect showed no significant difference between the two groups. Clinical manifestation, mucosal chronic inflammation and intestinal metaplasia improved more in WYA group than in FA group. Conclusion WYA, which could inverse intestinal metaplasia, is effective in treatment of CAG..