胃粘膜灶性异型增生的形态研究

Morphologic Study of Focal Dysplasia in Gastritis

３９６例活检胃粘膜炎症性病变中１９．９％找见异型增生灶，其由单个至１０多个细胞构成，可向管腔内或外突起。其检出率为糜烂性胃炎的８．０％，浅表性胃炎的１０．９％，萎缩性胃炎的３８．４％，慢性溃疡的１８．９％。灶性异型增生细胞ＰＣＮＡ阳性表达６１．３％；ＡｇＮＯＲ计数３．８１～８．７２个，提示ＰＣＮＡ和ＡｇＮＯＲ检测可帮助判断胃粘膜灶性异型增生。

cases of biopsied gastric mucosa with inflammation were studied pathologically. Focal dysplasia was found in 19.9% of the cases. Most of the foci consisted of 1-10 cells. The detectable rate of focal dysplasia was 8.0% in erosive gastritis,10. 9% in superficial gastritis,38.4% in atrophic gastritis and 18. 9% in chronic gastric ulcer.The positive rate of PCNA(proliferating cell nuclear antigen)in the focal dysplastic cells reached 61.3%.The count of AgNOR(nucleolar organizer regions) was between 3.81-8. 72.It indicates that the detection of PCNA and AgNOR might be helpful in the diagnosis of focal dysplasia of gastric mucosa.