整合蛋白α_5β_1和纤连蛋白与肝细胞癌生物学行为的关系

RELATIONSHIP BETWEEN THE EXPRESSION OF INTEGRIN α_5β_1 AND FIBRONECTIN AND THE BIOLOGIC BEHAVIOR OF HEPATOCELLULAR CARCINOMA

探讨整合蛋白α５β１和纤连蛋白（ＦＮ）表达与肝细胞癌（ＨＣＣ）生物学行为间的关系。应用免疫组化及图象分析技术对４０例ＨＣＣ组织作整合蛋白α５β１和ＦＮ定位及定量分析。结果：高分化ＨＣＣ组织整合蛋白α５β１和ＦＮ表达与正常及癌旁组织相近，而中、低分化ＨＣＣ中两者均明显减弱或消失；肿瘤浸润包膜处两种蛋白表达减少，但血管内癌栓外侧缘癌细胞整合蛋白α５β１和ＦＮ表达较强，并与相应血管内皮的强表达相映。结论：整合蛋白α５β１和ＦＮ表达的变化可能与ＨＣＣ分化、浸润及转移关系密切。

PURPOSE To study the relationship between the expression of integrin α5 β1, and fibronectin (FN) and the biologic behavior of human hepatocellular carcinoma (HCC). METHODS Integrin α β, and FN were immunohistochemically localized and quantitated with image analysis in tumor and peripheral liver tissues from 40 HCC cases. RESULTS The expression of integrin α5 β1 and FN in well differentiated HCC was not significantly different from that of normal and peripheral tissues, while they were markedly decreased or undetectable in moderately and poorly differentiated HCC. Decreased expression of integrin α5 β1, and FN at the sites where HCC invaded the connective tissue and enhanced expression on the HCC cells around cancerous emboli were also noted. CONCLUSIONS The change of expressing integrin α5 β1, and FN might be associated with HCC differentiation, invasion and metastasis.