3-烷基取代的焦脱镁叶绿酸-α甲酯衍生物的合成

Synthesis of methyl pyropheophorbide-αsubstituted at 3-position by alkyl group

以焦脱镁叶绿酸-α甲酯(MPP-α)为起始原料,在对其E-环羰基进行保护的前提下,经焦脱镁叶绿酸-α(Times new Rman)甲酯与1-乙基丙基溴化镁进行Grignard反应;所生成新的卟吩仲醇再经脱保护、脱水和氧化等诸多反应,将3-位仲羟基转化成碳碳双键和羰基,其碳氧双键再行Grignard反应并脱水成烯,完成一些未见报道的3-位烷基取代的焦脱镁叶绿酸衍生物的合成．其化学结构均经UV, IR,1HNMR及元素分析予以证实．

Methyl pyropheophorbide-α（MPP-α） was used as starting material. The carbonyl group on Ering of methyl pyropheophorbide-d was protected and the Grignard reaction with 1-ethylpropyl magnesium bromide was performed. The sec-alcohol obtained from Grignard reaction was subjected to deprotection, dehydrateion and oxidation to give mew methyl pyropheophorbide-α derivatives. The structures of the compounds were characterized by elemental analysis, UV, IR and H NMR spectra.