类风湿关节炎患者心理健康状况与血清可溶性P-选择素的相关性研究

The relative study on the level of mental health and serum soluble P-selectin in patients with rheumatoid arthritis

目的了解类风湿关节炎患者的心理健康水平以及与其血清可溶性P-选择素的相关性,为类风湿关节炎患者的康复治疗提供理论依据。方法(1)将来本院就诊和治疗的类风湿关节炎患者110名作为本次的研究对象,其他健康志愿者80名作为对照组。(2)分别进行症状自评量表(SCL-90)的测查。(3)利用酶联免疫吸附分析方法检测研究组血清sP-选择素水平。结果(1)类风湿关节炎患者心理问题检出率在29%左右,研究组SCL-90总分[(141.3±57)分、阳性项目数(35.1±20.5)分以及躯体化(1.78±0.57)分、焦虑(1.91±0.61)分、人际敏感(1.92±0.65)分和抑郁(1.93±0.63)分]四个因子分高于对照组[(114.9±31)分、(25.7±13.3)分、(1.69±0.49)分、(1.74±0.59)分、(1.78±0.74)分、(1.83±0.65)分],且存在显著性差异(P<0.01)。(2)SCL-90各因子(躯体化、强迫、人际敏感、抑郁、焦虑、敌对、恐怖性、偏执、精神病)与sP-选择素水平呈一定程度的正相关(r分别为0.553,0.673,0.457,0.750,0.698,0.333,0.509,0.312,0.331)。(3)心理问题检出组sP-选择素水平[(5018±1536)pg/ml]与相对正常组间sP-选择素水平[(3059±1091)pg/ml]差异存在显著性(P<0.01)。结论RA患者存在一定程度的心理问题,RA患者的病情及心理健康状况与其sP-选择素水平呈一定程度的相关。

Objective To study the relation to the level of mental health and serum soluble P-selectin in patients with rheumatoid arthritis. Methods 80 RA patients and 110 healthy people were tested with SCL-90 and 110 RA patients were tested with ELISA to get the data of their level on the soluble P-selectin to learn the relationship between the level of soluble P-selectin and psychological factors. Results SCL-90 total score（ 141.3 ± 57 ）, positive item count（35.1 ±20.5）, somatization score（ 1.78 ± 0.57 ）, anxiety score （1.91 ± 0. 61 ）, depression score （ 1.93 ± 0.63 ） in RA patients were higher than that of controls（ 114.9 ± 31,25.7 ± 13.3,1.69 ± 0.49,1.74 ±0.59,1.83 ±0.65）and correlation was existed between the scores of SCL-90 and level of soluble P-selectin in RA patients（ r=0.553,0. 673,0.457,0. 750,0. 698,0. 333,0. 509,0. 312,0. 331 ）. Conclusion RA patients had psychological impairment, and correlation was existed between to the psychological factors and level of soluble P-selectin in RA patients.