帕罗西汀加银杏叶提取物治疗抑郁症的疗效

The therapeutic effect of depression with Ginkgo leaves tablets and paroxetine

目的探讨帕罗西汀加银杏叶提取物对抑郁症的治疗效果。方法抽取门诊抑郁症患者86例,按就诊及确诊顺序编号,单号为研究组,双号为对照组。治疗观察时间为6周,以汉密顿抑郁量表(HAMD)为评定工具,分别对2组的治疗前后进行比较,2组的治疗后进行比较。结果2组治疗前后分别进行比较,均有显著性差异[研究组(21．23±4．25)分,(8．17±1．68)分；对照组(20．95±3．74)分,P＜0．01]。治疗后2组比较[研究组(8．17±1．68)分,对照组(10．34±2．17)分,(10．34±2．17)分；P＜0．05]。研究组治疗后各因子分均有明显下降,尤以焦虑/躯体化[(2．98±0．54)分,(1．14±0．83)分]、体质量[(1．83±0．53)分,(0．86±0．77)分]、日夜变化、迟滞、睡眠障碍、绝望感为著。对照组治疗后部分因子分也有明显下降,以焦虑/躯体化[(3．02±0．66)分,(1．98±0．97)分]、体质量[(1．95±0．71)分,(1．24±0．84)分]、认知障碍、日夜变化为著。治疗后2组HAMD各因子分比较,研究组在各因子的减分上明显好与对照组,尤以焦虑/躯体化、体质量、迟滞、睡眠障碍、绝望感为明显。结论帕罗西汀加银杏叶提取物治疗抑郁症疗效优于单用帕罗西汀,能有效改善抑郁及相关躯体症状。

Objective To investigate the therapeutic effect of depression with the Ginkgo Leaves Tablets and Paroxetine treatment. Methods Select the 86 depression patients who visited psycho clinic in Tang Du Hospital , nuinber them by the order of visiting and diagnosing, the single numbers are study group （ the Ginkgo Leaves Tablets and Paroxetine ） and the even numbers are control group （only Paroxetine ）. The two groups are all treated with Paroxetine, the dosage is 20mg, once in the morning daily. The patients in the study group should also take Ginkgo Leaves Tablets 19.2mg three times one day. Treat and observe for 6 weeks, evaluate by HAMD. Compare the two groups＇ score prior and post treatment respectively, compare the score of two groups after treatment. Results Compare the two groups prior and post treatment respectively, both had significant difference （21. 23 ±4.25,8.17 ±1.68 ;20.95 ± 3.74, P 〈 0.01 ）. There is difference between two groups post treatment（ 8.17 ± 1.68,10.34 ± 2.17,10.34 ± 2.17, P 〈 0.05 ）. Compare HAMD each factor score of study group prior and post treatment , every factor score decreased obviously post treatment, especially anxiety/somatization （ 2.98 ± 0.54, 1.14 ±0.83）, body weight（ 1.83 ±0.53,0.86 ±0.77）, change of day and night, hysteresis, dyssomnia, feeling of despair. Compare HAMD each factor score of control group prior and post treatment, every factor score also decreased obviously, especially anxiety/somatization （ 3.02 ± 0.66,1.98 ± 0.97 ）, body weight （ 1.83 ± 0.53,0.86 ± 0.77 ）, cognitive handicap, change of day and night, but the score of hysteresis, dyssomnia, feeling of despair didn＇t decrease obviously. Compare every factor score of two groups post treatment, every factor score of study group was much better than control group, especially anxiety/somatization, body weight, hysteresis, dyssomnia, feeling of despair. It means that therapeutic efficacy of study surpassed the control group obviously. Conclusion The therapeutic effect of the Ginkgo Leaves Tablets and Paroxetine treatment is better than using paroxetine only in the treatment of depression, can ameliorate depression and correlated body symptom efficiently and toleration is good.