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神经肽y与垂体腺瘤发病机制的关系 被引量:3

Relationship between Neuropeptide y and Estradiol-Induced Pituitary Adenoma in Rats
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摘要 目的:探讨雌激素诱发大鼠垂体腺瘤及神经肽y(NPy)与垂体腺瘤发病机制的关系。方法:将实验动物分为2组各30只。给药组雌性Wistar-Furth大鼠腹腔注射苯甲酸雌二醇,诱发垂体泌乳素细胞腺瘤;对照组大鼠腹腔注射等量生理盐水。而后观察2组大鼠脑组织和血浆中的神经肽y含量。结果:给药组Wistar-Furth大鼠产生垂体腺瘤,且血浆泌乳素浓度、NPy浓度和垂体及下丘脑NPy含量均明显升高。结论:NPy可能在垂体肿瘤的发生、发展过程中发挥着重要的作用。 Objective: To study the relationship between neuropeptide y (NPy) and pathogenesis of pituitary adenoma. Methods: Sixty Wistar-Furth rats were divided into experiment and control groups. The experiment group was injected with benzoic acid estradiol to induce pituitary adenoma, while the control group was injected with saline. After 60 and 120 days, plasma prolaetin (PRL) levels in both groups were measured by radioimmunoassary. NPy levels of pituitary gland, hypothalamus, pallium and plasma in both groups were also measured. Results: Estradiol could induce pituitary adenoma in Wistar-Furth rats. Serum PRL level in experiment group was higher than that of control group. NPy level was higher in pituitary adenoma, hypothalamus and serum in experiment group compared to that of control. Conclusion: This study demonstrated that NPy may play an important role in pathogenesis of pituitary adenoma
作者 王虎 马景鑑
出处 《天津医药》 CAS 北大核心 2006年第8期553-555,共3页 Tianjin Medical Journal
基金 国家自然科学基金资助项目(项目编号:30471772)
关键词 垂体肿瘤 腺瘤 神经肽y 大鼠 pituitary neoplasms adenoma neuropeptide y rats
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参考文献7

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二级参考文献8

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共引文献3

同被引文献15

  • 1甄自刚,马景砲,阎学江.垂体腺瘤患者血浆神经肽Y与垂体激素水平相关性研究[J].中华神经外科杂志,2005,21(10):612-615. 被引量:8
  • 2Laizhao Chen,Jingjian Ma,Anchao Zheng,Honggang Zheng.Expression of Neuropeptide Y in Human Pituitary Adenoma[J].Chinese Journal of Clinical Oncology,2006,3(1):25-31. 被引量:3
  • 3李守巍,胡志强,初明,王超.苯甲酸雌二醇与己烯雌酚诱导Fischer344大鼠泌乳素腺瘤的比较[J].中华神经外科杂志,2007,23(3):217-219. 被引量:2
  • 4盛学东,马景鑑.神经肽Y与垂体腺瘤相关性的研究进展[J].国际神经病学神经外科学杂志,2007,34(2):182-184. 被引量:1
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