摘要
目的探讨可溶性干细胞因子(SCF)及其受体(s-kit)与儿童慢性再生障碍性贫血(CAA)发病的关系。方法利用ELISA法测定CAA患儿、正常儿童外周血浆及脐血血浆s-kit及SCF水平。结果CAA组血浆s-kit水平(13.02±5.18)μg/L低于正常儿童组(17.82±5.36)μg/L和脐血组(19.0±5.63)μg/L,CAA组血浆SCF水平(365.5±98.35)μg/L,低于正常儿童组(469.26±102.32)μg/L和脐血组(567.22±135.88)μg/L。结论CAA组血浆s-kit及SCF水平降低,提示s-kit及SCF可能在儿童CAA发病中起一定作用。
Objective To investigate the function of soluble stern cell factor receptor （s-kit）and stem cell factor （SCF） in chronic aplastic anemia （CAA）. Methods ELISA assay was employed to determine the levels of s-kit and SCF in peripheral blood of CAA patients and umbilical cord blood. Results The levels of s-kit and SCF in peripheral blood of CAA patients are lower than those of normal group and umbilical cord blood group. Conclusions The decreased levels of s-kit and SCF show that s-kit and SCF may play a role in CAA mechanism. The raised levels of s-kit and SCF show that s-kit and SCF may be applied in the field of cord blood transplantation.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2006年第15期1000-1001,共2页
Journal of Applied Clinical Pediatrics
基金
河南省医学科技创新人才工程项目资助[豫卫科(2001)9]
