炎症因子在深静脉血栓形成及转归中的作用

To investigate the role of inflammatory cytokines in the formation and prognosis of deep vein thrombosis

目的研究白介素(IL)家族中的有关炎症反应因子和C-反应蛋白(CRP)在深静脉血栓形成(DVT)中的作用及其发病机制,探讨DVT患者的早期诊断和病程转归标志物。方法选择30例下肢DVT患者,按发病日程临床分为急性期和亚急性期。在治疗前(入院2h内)和治疗后第1、3、7、14天,分别检测IL-2、可溶性白介素2受体(slL-2R)、IL-4、IL-6、IL-8和CRP水平。结果治疗前及治疗后第1天,所有DVT患者sIL-2R、IL-6、IL-8和CRP水平较正常对照值显著升高(P＜0．01),急性期患者高于亚急性期患者,经治疗病情缓解后逐渐下降；而IL-4水平与正常对照值的差异无显著性(P＞0．05)。结论急性期和亚急性期DVT患者的sIL-2R、IL-6、IL-8和CRP水平升高,尤其CRP、sIL-2R可作为血液中早期炎症标志物和反映病情转归的炎症标志物。

Objective To investigate the role of inflammatory cytokines on interleukins（IL） family and C-reactive protein（CRP） in deep venous thrombosis（DVT） and its pathogenesis, and to appraise the early diagnostic and prognostic markers in DVT patients. Methods 30 DVT cases were divided into two groups： acute group and subacute group according to the course of illness. IL-2, sIL-2R, IL-4, IL-6, IL-8 and CRP were determined respectively two hours before treatment and 1, 3, 7, 14 days after treatment. Results Early in the disease, serum sIL-2R, IL-6, IL-8, and CRP showed higher level in the acute stage than those in the subacute stage. These cytokines declined after allcviation of the patients＇ condition, however, serum IL-4 showed no difference from the normal value. Conclusions sIL-2R, IL-6, IL-8 and CRP are all elevated significantly in acute and subacute stages of DVT patients（P 〈 0.01）, in particular, the CRP and solution interleukins-2 receptor-2R can be regarded as early diagnostic and prognostic inflammatory markers.