α-synuclein在帕金森病发病机制中的作用
被引量：1
摘要
帕金森病（parkinson disease，PD）是一种常见的神经变性疾病，以黑质多巴胺能神经元慢性进行性缺失和胞浆内嗜酸性包涵体（Lewy体）形成为病理特征。一直以来认为PD是环境因素引起的，随着家族性PD致病基因α-synuclein的发现，对PD的认识不断地加深，目前认为环境和遗传因素在PD的发生、发展中共同起作用。聚集的α-synuclein是PD和Lewy体痴呆以及其他神经系统变性疾病共有的特征，但是其致病作用还不清楚。近年来对α—synuclein的结构、功能和聚集的研究可能为我们对PD的认识提供新的见解。现就相关问题作一综述。
出处
《上海医学》
CAS
CSCD
北大核心
2006年第7期501-504,共4页
Shanghai Medical Journal
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