癌症恶病质的发生及治疗的实验研究

Experiments on the Development and Management of Cancerous Cachexia

癌症恶病质的主要表现是厌食和体重下降。本文动态观察了小鼠在腹腔注射ＴＮＦ－α及荷瘤后摄食量和体重的变化，采用ＲＩＡ测定各组小鼠血清ＴＮＦ－α水平。结果：１）ＴＮＦ－α能诱导小鼠摄食量和体重急剧下降。２）荷瘤组小鼠血清ＴＮＦ－α水平显著高于非荷瘤组（Ｐ＜０．０１）。３）ＮＰ治疗荷瘤小鼠，显著改善其摄食量和体重的下降。表明：ＴＮＦ－α与癌症恶病质的发生相关。用ＮＰ能有效拮抗恶病质的表现，延长荷瘤小鼠的生存。

Anorexia and weight loss are the main clinical manifestations of cancer associated cachexia. In this study the changes of food intake and body weight of both the mice injected intraperitoneally with TNF-α and the mice inoculated subcutaneously with LA795 were observed.Using RIA the TNF-α level in serum of mice in each group were assayed. The results showed that:(a) Administration of TNF-αto mice resulted in marked anorexia and weight loss.(b)The level of TNFα serum concentration in the tumor-bearing mice was significantly higher than those in nontumor-bearing mice (P<0.01). (c) Tumor-bearing mice treated with NP demonstrated a significant increase in food intake and body weight.The results suggest that TNF-α may be a mediator of cancer cachexia. Administration of NP has anticachectic effect.