^（131）I标记凝集素PNA在荷人胃癌裸鼠体内的分布

In vivo Distribution of ^(131)I-Labelled Peanut Lectin in Nude Mice Bearing Human Gastric Carcinoma

采用Ｉｏｄｏｇｅｎ法将放射性１３１Ｉ与花生凝集素（ＰＮＡ）进行标记，经腹腔注射１３１Ｉ－ＰＮＡ标记物到荷人胃癌裸鼠体内，在不同时间测定组织放射分布和γ照相。给药后第３天，肿瘤组织放射性强度是血液的４．３０倍，是正常肝组织的３．７６倍，是肌肉组织的３．８９倍；给药后第７天，肿瘤组织浓集１３１Ｉ－ＰＮＡ是正常胃组织的４．２１倍，是小肠组织的６．０５倍，是大肠组织的５．１３倍。４８小时可见肿瘤显像，７２小时显像清晰。本实验结果表明，凝集素ＰＮＡ在胃癌定位诊断和导向治疗中有着潜在的应用价值，对于人体某些表达Ｔ抗原的腺癌都可能具有作为导向治疗载体的研究前景。

Peanut agglutinin (PNA) was Labelled with 131I by means of Iodogen method and was injected intraperitoneally into tumor bearing nude mice.The tissue distribution of 131I-labelled PNA was studied and whole body scintigraphies were made at different times. At the 3rd day after administration,the distribution ratio of tumor to normal tissue (T/NT) was 4.30 for blood, 3.76 for liver and 3.89 for the muscle.At the 7th day after administration, the tumor to normal stomach ratio was 4. 21,tumor to colorectum ratio was 5. 13. The tumors could be visualized on r-camera imaging at 48hr after administration and clear tumor Picture in all animals receiving 131I-PNA at 72hr.These results suggest that PNA has Potential value in localizing tumor and targeting therapy of human stomach cancer as a targeting vehicle.