硫酸吗啡控释片控制癌性疼痛的疗效观察

Effect of Controlled-release Morphine Sulfate in the Treatment of Cancer Pain

１９９５年１～７月对１０５例伴有中－重度疼痛的晚期癌症患者应用硫酸吗啡控释片（ＭＳＴ）控制癌性疼痛。ＭＳＴ３０ｍｇ，ｐｏ．ｑ１２ｈ，给药时间为５～１９７天，平均２１．２天。平均初次剂量及最大剂量分别为５９．４ｍｇ／天和６５．６ｍｇ／天，其中９２例（８７％）患者不需增加初次剂量，１１例（１１％）患者需要增加剂量，范围在５０％～２００％之间。结果疼痛缓解率为９２％（９７／１０５）。对各种类型疼痛均有效，其中内脏痛缓解率和骨痛缓解率无显著性差异（Ｐ＞０．０５）。副作用主要是便秘２１％和恶心１１％，其中７２例（６９％）患者未出现任何明显副作用。作者强调剂量个体化，对慢性癌性疼痛应作为首选药物。

One hundred and five patients with chronic moderate or severe cancer pain were treated with controlled-release morphine sulfate(MST) from January 1995 to July 1995.MST was given orally at a dosage of 30mg every 12 hours over a duration from 5 to 197 days with a mean of 21.2 days.The mean daily first dose and maximum dose was 59.4mg and 65.6mg,respectively. 92(87%)patients didn't need to increase their daily first dosage. 11(11%)patients did.The range of increment was 50%-200%.The analgesic effect achieved was 92%(97/105).MST was effective in relieving all kinds of Pain,and no significant difference was noted between visceral pain and bone pain(P>0.05).The common side effects were constipation(21%)and nausea(11%).There were 72(69%)patients devoid of apparant side effects.The authors seriously recommend that MST should be the first choice in the control of chronic cancer pain and that its dosgae should be prescribed individually.