血清甲胎蛋白及铁蛋白在原发性肝细胞癌中的动态分析

Dynamic Analysis of Serum α-Fetoprotein and Ferritin in Primary Hepatic Carcinoma

观察３０例原发性肝癌病人血清ＡＦＰ及ＳＦ的治疗前、中及后动态变化，探讨其临床意义。结果发现，ＡＦＰ＞１０００ｎｇ／ｍｌ的初诊病人中，ＳＦ异常升高占１４／３０。同时，通过动态分析，发现ＳＦ与病情发展、治疗效果、预后等有关。作者认为，ＡＦＰ是一定性指标，以此为原发性肝癌主要的诊断依据，而ＳＦ则是一重要定量指标，表明疾病的发展程度，不能用于原发性肝癌的定性诊断。

In this article,the dynamic changes of serum AFP and SF at different phases(pre-treatment,during-treatment and post-treatment) were studied in 30 primary hepatic carcinomas(PHC)in order to assess their clinical significance.Our results showed that in untreated PHC Patients(AFP>1000ng/ml),only14/30 had abnormal elevation of SF.Meanwhile,the dynamic analysis showed that SF would indicate the status of disease,effect of treatment and prognosis etc.We consider that AFP is a qualitative indicator which serves as an importantdiagnostic evidence,whereas SF is a quantitative indicator which tells the degree of advancement of the disease,but not a pathognomonic feature of PHC.