学校恐怖症患儿局部脑血流灌注特征的初步研究

A pilot study of regional cerebral blood flow in children with school phobia

目的探讨学校恐怖症患儿局部脑血流灌注(rCBF)特征。方法对17例学校恐怖症患儿(研究组)和11名正常儿童(对照组)分别进行单光子发射型计算机断层显像检查,对研究组进行儿童焦虑性情绪障碍筛选量表的评估,比较两组rCBF的差异,以及rCBF与焦虑程度的关系。结果研究组左右额叶、右颞顶叶、左尾状核+壳核、左右颞叶、左丘脑+海马(P=0.05)、左右颞枕叶以及左右枕叶rCBF低于对照组(P≤0.01)；研究组右颞顶叶及右颞叶rCBF低于左侧(P＜0.05)；未发现焦虑程度与rCBF的改变存在相关性(P＞0.05)。结论学校恐怖症患儿可能存在rCBF障碍。

Objective To explore the characteristics of the regional cerebral blood flow （rCBF） in children with school phobia. Methods The single-photon emission commuted tomography were performed in 17 children with school phobia and 11 normal controls. The rCBF distribution in regions of interest （ROIs） was compared between the two groups. The degree of anxiety was assessed with the Screen for Child Anxiety Related Emotional Disorders, and the correlation between the degree of anxiety and rCBF was calculated. Results The rCBF in the right temporoparietal lobe and temporal lobe were significantly lower than that in the left ones in children with social phobia （ P 〈0. 05 ）. The rCBF in frontal lobe, right temporoparietal lobe, left caput and putamen, temporal lobe, left thalamus and hippocampus, temporo- occipital and occipital lobe were significantly lower in phobia children than in controls （ P 〈 0. 05 ）. There was no significant correlation between the rCBF and the degree of anxiety （ P 〉 0. 05 ）. Conclusion There are possible regional cerebral flow changes in children with school phobia.