头孢菌素类药物致双硫醒样反应45例临床研究

Clinical study on 45 disulfiram-like reactions caused by cephalosporin

目的探讨应用头孢类药物时饮酒所致双硫醒样反应与急性酒精中毒的临床差异。方法比较头孢类药物致双硫醒反应与急性酒精中毒两组患者的临床表现、颜面充血程度、血酒精浓度、平均动脉压、心率的变化。结果（1）两组患者临床表现有明显差异。（2）在酒后30～120min，单纯急性酒精中毒组血酒精浓度明显高于双硫醒样反应组（P〈0．01），但后者面部充血程度明显重于前者（P〈0．05）、心率加快也明显高于前者（P〈0．05），两组的平均动脉压变化无明显差异。结论使用头孢类药物时饮酒所致双硫醒样反应与头孢类药物有关，与饮酒的量无相关性。

Objective To study the different clinical characteristics between the Disulfiram-like Reactions （DLR） Caused by Cephalosporin and the acute alcoholism（AA） toxicosis. Methods The clinical manifestation,the degree of flushing,the blood ethanol concentration,mean arterial pressue and heart rate were companced between two groups. Results （ 1 ） The chnical manifestation had signifiant difference between two groups. （ 2 ） During 30 - 120 min after the consumption of alcohol, the blood ethanol concentration of AA group was higher than that of DLR group （P 〈 0.01 ） ,mean arterial pressue has no difference,but the degree of flushing and the heart rate of DLR group were obviously higher than those of AA group （ P 〈 0.05 ）. Conclusion DLR correlates with the Cephalosporin but does not correlate with the quantity of consumption of alcohol.