米索前列醇配伍依沙吖啶终止16~18周妊娠临床分析

Clinical analysis on pregnancy termination in 16～18 gestational weeks by using ethacridime with misaprostol

目的探讨米索前列醇（以下简称米索）配伍依沙吖啶终止16—18周妊娠的效果。方法电脑随机号法将92例16—18周妊娠妇女分成A、B、C三组，均在B超监护下行依沙吖啶羊膜腔穿刺术，术后15min分别阴道内塞米索400斗g（A组）、米索2001μg（B组）、甲硝唑200mg（C组）。结果A、B两组出现规律宫缩时间、胎儿胎盘排出时间明显缩短，与C组比较差异有统计学意义（P〈0．05）；A、B两组胎盘胎膜残留率、引产失败率、出血量均降低，与C组比较差异有统计学意义（P〈0．05），但A、B两组间差异无统计学意义。结论米索配伍依沙吖啶引产安全有效，能缩短产程。

Objective To study the clinical effect of Misoprostol combined with rivanol to stop pregnancy during 16- 18weeks. Methods 92 pregnancy women（ 16 - 18weeks） were randomly divided into three groups, misoprostal （400 μg） in group A,misoprostal （200 μg） in groups B,metronidazole （200 mg） in groups C were respectively placed into vaginal tract 15minutes after rivanol injected in amniotic cavity by B-ultrasonics guide. Results The time of viginal haemorrhage, foetus placenta removal, incidence of placenta fetal membranes remaining, failure labor and volume of haemorrhage were sigincficantly lower in group A and B than that in group C （ P 〈 0.05 ）. but there were no sigincficant diffirence between group A and B. Conclusions The misoprostal combined with rivanol is a safe and effective method for the induced labor.