支气管动脉灌注化疗治疗肺癌42例临床分析

Clinical Analysis on Treatment of 42 Case Non-small Cell Lung Cancer with Bronchial Arterial Infusion Chemotherapy

目的探讨经支气管动脉灌注化疗治疗非小细胞肺癌的疗效、安全性和并发症的防治。方法回顾性分析42例行支气管动脉灌注化疗的非小细胞肺癌患者临床治疗经过。经右侧股动脉插管,采用Seldinger技术插管至降主动脉,造影显示支气管动脉,选择靶血管灌注化疗药物。结果完全缓解4例,部分缓解28例,稳定6例,进展4例;总有效率为76.2%。所有病例无严重并发症。结论经支气管动脉灌注化疗是治疗非小细胞肺癌的1种安全、有效的方式。

Objective To investigate the therapeutic efficacy, safety and complication of bronchial artery infusion （BAI） chemotherapy in patients with non- small cell lung cancer （NSCLC）. Methods Forty-two patients suffering moderate or advanced NSCLC confirmed by pathology were observed and infused with carboplatin, iphosphamide plus hydroxycamptothecin or carboplatin combined with paclitaxel into bronchial artery via a catheter by the Seldinger technique. Results After treatment the total effect rate （CR ＋ PR） was 76.2 % （32/42） with tumor lesion disappearance in 4 case,significant tumor regression in 28 cases and most of the cases had alleviation of clinical symptoms. In the course of the therapy, no severe complications appeared. Conclusion Bronchial artery infusion chemotherapy is a ,safe and effective therapies in NSCLC.