复方丹参滴丸对中晚期乳腺癌化疗的影响

The Effect of Composite Salviae Dropping Pill Combined with Chemotherapy in Patients with Advanced Breast Carcinoma

目的:评价复方丹参滴丸联合NP方案治疗中晚期乳腺癌的疗效、免疫功能、生存质量和毒副反应。方法:100例中晚期乳腺癌患者随机分为联合组、单纯化疗组,联合组(51例)采用复方丹参滴丸加NP方案治疗,单纯化疗组(49例)采用单纯NP方案化疗,进行近期疗效、免疫功能、生存质量和毒副反应的随机对照研究。结果:联合组、单纯化疗组的有效率分别为56.9%和46.9%(P>0.05),临床获益率分别为92.2%和73.5%(P<0.05),联合组治疗后T淋巴细胞亚群中的CD4/CD8比值有明显提高(P<0.01),而单纯化疗组治疗后T淋巴细胞亚群中的CD4/CD8比值有明显减低(P<0.01),生存质量联合组高于单纯化疗组(P<0.05),恶心呕吐、感觉神经毒性、白细胞减少及粘膜炎单纯化疗组高于联合组(P<0.05)。结论:复方丹参滴丸联合化疗治疗乳腺癌能提高患者的治疗临床获益率、增强乳腺癌患者的细胞免疫功能,提高生存质量、减轻化疗某些不良反应。

Objective： To observe the therapeutic effect, the cell immunology, quality of life and toxicity in advanced breast carcinoma treated with composite salviae dropping pill in combination with NP regimen chemotherapy. Methods： 100 patients with advancod breast carcinoma were randomly divided to receive NP regimen combined with composite salviae dropping pill（ combined group, 51 cases） or NP regimen only（chemotherapy alone group, 49 cases）. Results： The objective response rate（ Complete remission ＋ Partial ression, CR ＋ PR） was 56. 9% in combined group, compared to 46. 9% in chemotherapy alone group （ P 〉 0. 05）, the clinical benefit response rate（ Complete Remission ＋ Partial Bession ＋ Stable Disease, CR ＋ PR ＋ SD） was 92. 2% in combined group, compared to 73. 5% in group of chemotherapy （P 〈 0. 05）, the level of CD4/CD8 was significantly increased in combined group （P 〈 0. 01 ）, the level of CD4/ CD8 was significantly decreased in group of chemotherapy along（P 〈0.01）, quality of life in combined group was higher than that in group of chemotherapy along（P 〈0. 05）. Nausea, vomiting, sensory neurotoxicity, leukopenia, and mucitis in group of chemotherapy alon were more serious than in combined group （P 〈 0. 05）. Conclusion： Composite salviae dropping pill can give a satisfactory clinical henefit response rate, decrease side effects of chemotherapy, improve quality of life in the patients with breast carcinoma and enhance the immunofunetious of the patients with breast carcinoma treated with chemotherapy.