重度妊高征患者血清游离氨基酸和氨的定量分析

DeterminationofSerumFreeAminoAcidsandAmmoniainPregnantWomenwithSeverePregnancyInducedHypertension

目的：分析重度妊高征患者血清游离氨基酸和氨的变化。方法：采用氨基酸自动分析仪对３３例重度妊高征患者（妊高征组）和２９例正常妊娠妇女（对照组）血清中１６种游离氨基酸及氨进行定量分析，并检测其中部分患者红细胞压积（ＨＣＴ）和血红蛋白（Ｈｂ）含量，对血清中总游离氨基酸含量与ＨＣＴ和Ｈｂ间的相关关系进行比较。结果：妊高征组呈现高氨基酸血症和氨血症，高芳香族氨基酸（苯丙氨酸和酪氨酸）血症，高苏氨酸、谷氨酸、甘氨酸、胱氨酸和精氨酸血症。子痫患者血清中谷氨酸的含量明显高于先兆子痫患者。妊高征组血清总氨基酸的含量与ＨＣＴ和Ｈｂ间存在着明显的负相关关系。结论：重度妊高征患者存在着明显的高氨基酸血症和氨血症，并可能与本病的高血压和脑部症状有关。

Objective:Todeterminethechangesofserumfreeaminoacidsandammoniainpreg-nantwomenwithseverepregnancyinducedhypertension(PIH)andtoevaluateitssignificance.Methods:16kindsoffreeaminoacidsandammoniainmaternalserumweremeasuredbyauto-aminoacid-analyzorin33caseswithseverePIHand29normalpregnancies.Haematocrit(HCT)andhemoglobin(Hb)insomeofthesampleswerealsodetermined.ThecorrelationbetweenHCT,Hbandthetotalfreaminoacidwerestudied.Results:ThegroupwithPIHshowedthefolowingchanges:aminoacidemiaandammonemia;higharomaticaminoacidemia;highthreonine,arginine,glycine,cystineandglutamicacidemia.Thelevelofglutamicacidwasobviouslyhigherintheeclampsiapatientsthanthatinthepreeclampsiaones.ThereexistedanegativecorelationbetweenthequantitiesofthetotalaminoacidandHCTandHbinPIHgroup.Conclusion:TherewereaminoacidemiaandammonemiainPIHpatients.Thehighlevelsofsomeaminoacidsmightberelatedwiththepathogenesisofhypertensionandthecerebralsymptoms.