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围产儿腹裂畸形的全国流行病学调查 被引量:6

EpidemiologyofGastroschisisinChina
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摘要 目的:探讨我国围产儿腹裂畸形的临床表现和流行病学特征,为预防和治疗提供科学依据。方法:1986年10月~1987年9月间,在我国原29个省、市、自治区945所医院,对妊娠28周至出生后7天的围产儿进行出生缺陷监测。结果:在监测的1243284例住院分娩围产儿中,共检出腹裂194例;全国平均发生率为1.6/万;各省发生率从0.4/万至3.4/万。山东省发生率最高(3.4/万),与全国平均水平比较,差异有显著性(P<0.01)。低体重儿中腹裂发生率(1.6/万)高于正常体重儿(0.6/万,P<0.01);乡村发生率(2.5/万)高于城镇(1.1/万,P<0.01)。70.6%的腹裂伴有其他畸形。患儿围产期死亡率91.8%,且多发畸形的腹裂死亡率(95.6%)显著高于单发腹裂畸形(82.5%,P<0.01)。产前诊断的腹裂畸形仅占15.0%。结论:我国围产儿腹裂畸形的状况与国外比较,产前诊断率低,畸形严重,且常伴有其他多发畸形,围产期死亡率高。 Objective:Tostudytheclinicalandepidemiologiccharacteristicsofperinateswithgastroschisis(GA)inChina.Methods:Thebirthdefectsmonitoringprogramwasundertakenin945hospitalsfrom29provinces,citiesandautonomousregionsofChina.Dataaboutperinatesincludingintrauterinedeathandstilbirthfrom28weeksofgestationtoaperiodof7daysafterbirthwascol-lectedthroughthemedicalrecordsbetweenOctober1986andSeptember1987.Results:Atotalof194caseswithGAwasfoundin1243284perinatesmonitored.TheincidenceofGAinChinavariedfrom0.4to3.4withameanof1.6per10000.ThehighestprevalencewasinShandongprovince(3.4/10000)whichwassignificantlyhigherthantheaverage(P<0.01).TheprevalenceofGAperinateswithlowbirthweightwashigherthanthatwithnormalbirthweight(1.6vs0.6per10000,P<0.01),aswelasthatintheruralareahigherthanintheurbanarea(2.5vs1.1per10000,P<0.01).70.6%ofthecaseswithGAwereacompaniedwithothermajordefects.Theover-alperinatalmortalityrate(PMR)ofGAwas91.8%.PMRofGAwithotherbirthdefects(95.6%)wassignificantlyhigherthanthatofGAonly(82.5%,P<0.01).Only15%ofGAwerediagnosedbeforebirth.Conclusions:GAwasaseriousmalformation.CaseswithGAhadhighPMRandlowdetectionratesinprenataldiagnosis,andmostoftenacompaniedwithmultipledefects.
出处 《中华妇产科杂志》 CAS CSCD 北大核心 1996年第7期397-400,共4页 Chinese Journal of Obstetrics and Gynecology
关键词 腹部 畸形 围产期学 流行病学 AbdomenAbnomalitiesPerinatologyEpidemiology
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  • 1周光萱,朱军,代礼,王艳萍,粱娟,缪蕾.1996至2000年全国先天性腹裂畸形监测资料分析[J].中华预防医学杂志,2005,39(4):257-259. 被引量:25
  • 2张旭东,周磊,张小华,郭鹏.先天性腹裂Ⅰ期修补的体会[J].临床小儿外科杂志,2005,4(4):297-298. 被引量:2
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