胎儿生长迟缓孕妇淋巴细胞姐妹染色单体的互换频率

StudyonSisterChromatidExchangeinLymphocytesofWomenwithFetalIntrauterineGrowthRe┐tardation

目的：了解胎儿生长迟缓（ＩＵＧＲ）孕妇外周血及新生儿脐血姐妹染色单体互换（ＳＣＥ）频率的变化。方法：应用姐妹染色单体互换技术，对１４例单纯性ＩＵＧＲ孕妇（ＩＵＧＲ组）及９０例正常孕妇（对照组）的外周血及其所分娩新生儿脐血ＳＣＥ频率进行测定。结果：ＩＵＧＲ组外周血及脐血ＳＣＥ频率分别为１０．５３±２．６９，７．２５±１．３４；对照组外周血及脐血ＳＣＥ频率分别为７．５８±０．３２，５．０５±０．２９；两组比较，差异有极显著性（Ｐ均＜０．０１）。ＩＵＧＲ组外周血及脐血ＳＣＥ频率全部异常。结论：ＩＵＧＲ与遗传物质损伤有关，ＳＣＥ频率有可能作为一项诊断ＩＵＧＲ的新指标。

Objective:Tostudysisterchromatidexchange(SCE)frequencyinlymphocytesofpregnantwomenwithintrauterinegrowthretardation(IUGR)infants.Methods:ThefrequencyofSCEinperipheralbloodlymphocytesof14pregnantwomenwithIUGRbabiesand90normalpreg-nantwomenaswelastheumbilicalbloodoftheirinfantswereinvestigated.Results:Themeanfre-quencyofSCEinmaternalandumbilicalbloodwithnormalpregnancywere7.58±0.32and5.05±0.29respectively,whiletheywere10.53±2.69and7.25±1.34inIUGRgrouprespectively.ThediferenceofSCElevelsbetweenthe2groupsofmotherwasstatisticalysignificant(P<0.01),sowasthatoftheumbilicalbloodgroup.Conclusion:OneofthecausesofIUGRmayberelatedtoheredityinjury.Thus,SCEwilbeanewdiagnosticindextopredictIUGR.