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(3R，5S)-6-氧代-3，5-O-亚异丙基-3，5-二羟基己酸叔丁酯的合成 被引量：2

Synthesis of t-Butyl (3R,5S)-6-oxo-3,5-O-isopropylidene-3,5-dihydroxyhexanoate
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摘要 L-(一)-苹果酸经酯化、还原、羟基保护、缩合、羰基还原、羟基保护、脱硅保护和Swern氧化等反应制得罗伐他汀的关键中间体(3R,5S)-6-氧代-3,5-O-亚异丙基-3,5-二羟基己酸叔丁酯,总收率25%。 t-Butyl （3R,5S） -6-oxo-3,5-O-isopropylidene-3,5-dihydroxyhexanoate, a key intermediate of rosuvastatin, was synthesized from L- （-） malic acid by esterification, reduction, hydroxyl protection, condensation, carbonyl group reduction, hydroxyl protection, deprotection and Swern oxidation with an overall yield of 25%.
作者 高晶 王健 王丹丹 潘莉 程卯生
机构地区 沈阳药科大学制药工程学院
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2006年第8期515-517,共3页 Chinese Journal of Pharmaceuticals
关键词 (3R 5S)-6-氧代-3 5-O-亚异丙基-3 5-二羟基己酸叔丁酯 罗伐他汀 中间体 合成 t-butyl （3R,5S） -6-oxo-3,5-O-isopropylidene-3,5-dihydroxyhexanoate rosuvastatin intermediate synthesis
分类号 R914.4 [医药卫生—药物化学]
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参考文献5

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共引文献3

同被引文献24

  • 1Reinhold O, Gabriele B. Process for the preparation of intermediates useful in the synthesis of statin derivatives especially [P]. WO: 03 004450, 2003-01-16.
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二级引证文献4

中国医药工业杂志
2006年 第8期

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