老年冠心病患者血浆内皮素浓度变化

The changes of plasma endothelin levels in patients with senile coronary artery disease

采用放射免疫法测定３６例老年及老年前期冠心病患者及健康人血浆内皮素（ｅｎｄｏｔｈｅｌｉｎ，ＥＴ）水平的变化。结果显示：①老年前期组（＜６０岁）冠心病患者与健康人血浆内皮素水平（９．８２±２．５８）ｎｇ／Ｌ和（７．２６±１．４５）ｎｇ／Ｌ无明显差异（Ｐ＞０．０５）；老年组（≥６０岁）冠心病患者与健康人血浆ＥＴ水平（１３．６３±３．１０）ｎｇ／Ｌ和（７．９３±１．８６）ｎｇ／Ｌ差异显著（Ｐ＜０．０１）。②老年组冠心病患者血浆ＥＴ水平（１３．６３±３．１０）ｎｇ／Ｌ较老年前期组（９．８２±２．５８）ｎｇ／Ｌ明显升高（Ｐ＜０．０５）。提示：老年冠心病患者心肌缺血及血管内皮细胞损伤严重，血浆ＥＴ水平可以作为老年冠心病患者判断病情及预后的参考指标之一。

Plasma endothelin(ET)levels in 36 patients with coronary artery disease(CAD) and 24 healthy people were determined with radioimmunoassay. The result showed:1.In the presenile group(<60 years of age)the plasma ET levels(9.82±2.58)ng/L were not significantly different from those in healthy subjects(7.26±1.45)ng/L(P>0.05), while in the senile group(≥60 years of age) were significantly different(P<0. 01).2. The plasma ET levels of CAD patients in the senile group(13. 63±3. 10) ng/L were significantly higher than those in the presenile group(9. 82±2.58)ng/L(P<0.05). The result indicates that in the senile CAD patients, ischemia of myocardium and the impairment of vascular endothelial cells are serious, and that plasma ET levels may be one of the indices to the prognostic judgement of these patients.