吸入氟替卡松联用孟鲁司特对婴幼儿哮喘的防治作用

Effect of Inhalation Fluticasone Combining with Montelukast in the Therapy and Prevention of Asthma in Infants and Young Children

目的观察吸入氟替卡松的基础上联合应用孟鲁司特在婴幼儿哮喘防治中的作用。方法采用随机分组方法,将63例中-重度婴幼儿哮喘患者分3组:吸入氟替卡松联用孟鲁司特组为A组(n=24)、单吸入氟替卡松为B组(n=22)、把不依从治疗者的作对照组C组(n=17)进行6个月的治疗,观察各组患儿在6个月的研究期中发生急性发作时的哮喘症状评分、每次发作持续的天数、发作次数和全身使用糖皮质激素的总量。结果规律吸入氟替卡松并联合每天口服孟鲁司特组的患儿哮喘的症状评分、每次发作持续的天数、发作次数和全身使用糖皮质激素的总量明显低于单吸入氟替卡松组和对照组,(P<0.01);单吸入氟替卡松组的患儿哮喘症状评分、每次发作持续的天数、发作次数和全身使用糖皮质激素的总量也明显低于对照组。(P<0.01)。结论在吸入氟替卡松的基础上联合应用孟鲁司特可显著提高婴幼儿哮喘的疗效。同时减少全身糖皮质激素使用量。

Objectives On the basis of Fluticasone inhalation, to investigate the effect of inhalation Fluticasone combining with Montelukast in therapy and prevention of Asthma in infants and young children, lethods 63 cases of moderate-to-severe asthma in infants and young children were randomly divided into three groups： daily inhalation of Fluticasone combining with Montelukast （group A, n=24）, inhalation of Fluticasone alone （group B, n=22） , those didn＇t adhere to the therapy served as control （group C, n=17）. The study period was six months. The end point of the study was mean asthmatic symptoms score, the length of each exacerbation episode, the number of acute exacerbation, the total amount of systemic corticosteroids used. Results The asthmatic symptoms score, the length of each exacerbation episode , the number of exacerbation, and the total amount of systemic corticosteroids used of group A were significantly lower than those of the group B and the control group, （P〈0. 01）; the asthmatic symptoms score, the length of each exacerbation episode ,the number of exacerbation, and the total amount of systemic corticosteroids used of group B was also significantly lower than those of the control group （P〈0. 01）. Conclusions On the basis of daily inhalation of Fluticasone, combining inhalation of Fluticasone with Motelukast can significantly improve the therapeutic effect and lower the total amount of systematic corticosteroid used.