477例健康体检者乙型肝炎血清流行病学分析

Seroepidemiological Analysis of Hepatitis B virus Infection Among 477 Cases of the Physical Check-up

目的了解健康人群乙型肝炎(乙肝)病毒血清学标志的表现模式,探讨乙肝预防的对策与措施。方法对开平市某工厂477名健康体检者采用ELISA法检测乙肝标志物(HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc)五项血清学指标。结果HBV感染率为93.71%;HBsAg、抗-HBs阳性率为13.00%、70.23%,性别间有显著性差异(P>0.05);其感染模式有9种,以抗-HBs+抗-HBc、抗-HBs、抗-HBc阳性模式多见,其构成比分别为46.09%、28.19%、10.96%。结论HBV感染在我市健康人群中仍有较高的感染率,且男性感染率较女性高;对成年人应采取预防和干预措施;乙肝疫苗接种可对未感染者进行有效保护,同时也影响着人群HBV的感染模式。

Objective To understand the serological changes of hepatitis B virus markers（HBVMs） from individual physical check-up, and provide theoretic basis for the prevention of hepatitis B virus. Methods HBsAg, anti-HBs、 HBeAg、 anti-HBe、 anti-HBc testing by ELISA were performed for 477employees in one factory of Kaiping city. Results The total infectious rate of HBY was 93.71%, The positive rate of HBsAg and anti-HBs were 13.00% and 70.23% respectively whose difference between man and woman were statistically significant （P〉0.05）. All HBV infections had 9 types of HBVMs, Most commonly HBVMs were anti-HBs positivity with anti-HBc positivity 、anti-HBs positivity、anti-HBc positivity, whose constituent ratio were 46.09%-28.19% and 10.96% respectively. Conclusion The infectious rate of HBV is still on high level of which man were infected highly than woman. It is necessary for adults to take preventive and controlled measures. Heptitis B vaccination can not only protect the healthy individual, but also change the HBVMs.