羟丙甲纤维素性质对布洛芬-羟丙甲纤维素凝胶骨架片释放度的影响

EFFECT OF PHYSICOCHEMICAL PROPERTIES OF HYDROXYPROPYL METHYLCELLULOSE ON DISSOLUTION RATE OF IBUPROFEN-HYDROXYPROPYL METHYLCELLULOSE MATRIX TABLETS

研究羟丙甲纤维素（ＨＰＭ）理化性质对布洛芬－ＨＰＭＣ凝胶骨架片释放度的影响。用转篮法测定布洛芬的释放度。结果：药物的体外释放符合Ｈｉｇｕｃｈｉ方程。药物的释放度与ＨＰＭＣ的粘度、粒度以及用量有关：ＨＰＭＣ粘度越大、粒度越小，药物的释放度越慢；药物与ＨＰＭＣ的比例对药物的释放度有明显影响。结论：药物从骨架片中的释放度与ＨＰＭＣ的理性质有关。

PURPOSE To study the effect of physicochemical properties of hydroxypropyl methylcellulose (HPMC) on dissolution rate of ibuprofen-HPMC matrix tablets. METHODS Dissolution rate of ibuprofen from the matrix tablets was determined by rotary basket methed. RESULTS It was found that the dissolution rate of ibuprofen-HPMC matrix tablets conformed to Higuchi equation. Higher viscosity and smaller particle size of HPMC gave slower drug release. Variation in drug/ HPMC proportion showed significant difference in dissolution rate of ibuprofen. CONCLUSIONS The dissolution rate of drug from matrix was dependent on the physicochemical properties of HPMC.