胰腺癌的Ki-67抗原表达

Ki-67 antigen expression in pancreatic cancer

应用Raine Ki-67等效抗体(MIB-1)测定40例胰腺癌和10例慢性胰腺炎中Ki-67核抗原的表达,结果发现:这种新型Ki-67等效抗体在石蜡切片中显示了较好的敏感性和特异性;胰腺癌癌巢细胞中Ki-67抗原的表达明显高于非癌巢细胞和慢性胰腺炎,而且Ki-67指数与胰腺癌组织学分级高度相关,提示Ki-67核抗原的测定有助于肿瘤临床病理分级诊断。

The expression of Ki-67 antigen was evaluated in 40 cases of pancreatic cancer and 10 cases of chronic pancreatitis by MIB 1 immunohistochemistry. The result showed that Ki-67 immuno-staining by MIB 1 is a simple and reliable technique for the routine estimation of cell proliferation and malignant tendency in pancreatic cancer. A correlation between Ki-67 expression and histologic grades was observed in pancreatic cancer, suggesting that MIB 1 immuno-staining may be helpful in pathological diagnosis.