结节性筋膜炎的免疫组织化学检测

IMMUNOHISTOCHEMICAL STUDY OF NODULAR FASCIITIS

①目的探讨结节性筋膜炎的组织来源和细胞分化，以及免疫组织化学检测对其鉴别诊断的意义。②方法用波形蛋白（Ｖｉｍ）、结蛋白（Ｄｅｓ）、平滑肌肌纤蛋白（ＳＭＡ）、肌红蛋白（ＭｙＧ）、肌球蛋白（Ｍｙｓ）、Ｓ１００蛋白（Ｓ１００）、神经原纤维（ＮＦ）、Ⅷ因子相关抗原（Ⅷｆ）、溶菌酶（Ｌｙｓ）和α１抗胰蛋白酶（ＡＡＴ）进行免疫组化标记。③结果病灶中纤维母细胞样细胞对Ｖｉｍ，ＳＭＡ，ＭｙＧ，Ｍｙｓ，Ｓ１００蛋白、Ｌｙｓ和ＡＡＴ呈不同程度阳性反应，实验结果支持病灶起源于间叶组织细胞，并具有向平滑肌、横纹肌、组织细胞及血管等多向分化能力。

Objective To study the histogenesis and differentiation of nodular fasciitis and the significance of immunohistochemical examination in diagnosis.Method Twenty five cases of nodular fasciitis were studied with various immunohistochemical stains: Vim,Des,SMA,MyG,Mys,S100,NF, ⅤⅢ f,Lys and AAT.Results The fibroblastic cells displayed positive staining of Vim,SMA,MyG,Mys,S100,Lys and AAT,which suggested that these fibroblastic cells arose from primitive mesoblastic cells and tended to differentiate into various tissues or cell: smooth muscle,striated muscle,histocyte and blood vessel.Conclusion This study indicates that the immunohistochemical method is of considerable value in the differential diagnosis of nodular fasciitis.