摘要
目的探讨生存素在子宫内膜异位症病灶及在位内膜中的表达情况及相关因素。方法采用免疫组化抗生物素蛋白-过氧化物酶染色法(SP法)检测38例2002年12月至2004年9月在我院妇科住院的未经治疗的子宫内膜异位症患者的异位及在位内膜标本中生存素的表达,以同期因子宫肌瘤或宫颈病变接受手术的生育期妇女的子宫内膜作为对照。结果病例组异位内膜与在位内膜均有生存素的表达并且缺乏周期性变化(P>0.05),异位内膜腺上皮生存素表达的强度高于在位内膜(P<0.05)。结论子宫内膜异位症的异位及在位内膜均表达生存素,而且在位内膜间质及异位内膜腺上皮表达也缺乏周期性。
Objective To find out the expression of survivin, a member in the inhibitor of apoptosis protein family, in both ectopic and eutopic endometrium from women with different stages of endometriosis. Methods A total of 38 patients with untreated endometriosis who were admitted to the gynecology department from Dec, 2002 to Sep, 2004 were enrolled in this study. 40 samples of ectopic endometrium were collected and detected for survivin expression, using immunohistochemical technique. Results Survivin expression could be observed in both ectopic and eutopic endometrium from patients with endometriosis and was lack of periodicity （P〉0.05）. Compared with eutopic endometrium, survivin expression in ectopic lesion has a larger quantity （P〈0. 05）.Conclusionoth eutopic and ectopic endometium of endometriosis patients express survivin but the expression was lack of periodicity during the menstrual cycle.
