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81例乳腺癌PTEN表达及与预后关系 被引量：1

PTEN Expression in 81 Cases with Breast Cancer and Its Prognostic Significance
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摘要 [目的]探索PTEN在乳腺癌组织不同临床病理参数下的表达及与预后关系。[方法]对1989全年81例乳腺癌病例,应用免疫组化SP法检测乳腺癌组织中PTEN的表达,对不同临床病理参数下的表达及对术后5年、10年和15年生存率的影响进行分析。[结果]PTEN表达的阴性率为33.33%(27/81),阳性率为66.67%(54/81)。Her-2/neu阳性表达标本中PTEN阳性表达率为47.23%,Her-2/neu阴性表达标本中PTEN阳性表达率为82.22%,Her-2/neu阴阳性之间的PTEN表达有显著性差异(P<0.01);而其它如绝经状态、肿块大小、病理类型、腋淋巴结和ER状态之间的PTEN表达无显著性差异。PTEN阴性表达患者的5年、10年的生存率显著低于PTEN阳性表达的患者。[结论]PTEN失表达提示乳腺癌术后生存时间较短。PTEN可以作为分子标记物辅助临床判断乳腺癌的预后。
作者 吴雪花 丁克峰
机构地区 浙江省青春医院 浙江大学附属第二医院
出处 《肿瘤学杂志》 CAS 2006年第4期311-313,共3页 Journal of Chinese Oncology
关键词 乳腺肿瘤 PTEN 生存率 预后
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献5

  • 1吴元清,魏启幼.PTEN在乳腺癌研究中的进展[J].国外医学（生理病理科学与临床分册）,2003,23(6):577-580. 被引量：9
  • 2Depowski PL, Rosenthal SI, Ross JS. Loss of expression of the PTEN gene proein product is associated with poor outcome in breast cancer[J]. Mod Pathol, 2001,14: 672-676.
  • 3Pianetti S, Arsura M, Romieu-Mourez R, et al. Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of ⅠkappaB-alpha that can be inhibited by the tumor suppressor PTEN[J]. Oncol Gene, 2001, 20(11):1287-1299.
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二级参考文献23

  • 1Lee J, Georgescu M, Di Cristofano A, et al. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association [ J ]. Cell, 1999,99 ( 3 ):323 -334.
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  • 7Weng LP, Brown JL, Eng C, et al. PTEN coordinates Gl arrest by down-regulating cyclin Dl via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model [ J ]. Hum Mol Genet, 2001 , 10 ( 6 ) :599-604.
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共引文献8

同被引文献24

  • 1薛锋杰,代志军,王西京,刘小旭,赵世平,康华峰,闵卫利.抑癌基因PTEN在乳腺癌中的表达及其临床意义[J].实用医技杂志,2004,11(10B):2114-2116. 被引量：4
  • 2张宏艳,宋三泰,江泽飞,郑晓玲,黄焰,李刚.乳腺癌组织中PTEN的表达及其临床意义[J].解放军医学杂志,2006,31(10):963-965. 被引量：7
  • 3夏愔愔,詹思延.如何撰写高质量的流行病学研究论文 第七讲 随机对照试验Meta分析的报告规范——QUOROM介绍[J].中华流行病学杂志,2007,28(6):618-620. 被引量：8
  • 4Chen J, Li S, Yang Z, et al. Correlation between NDRG1 and PTEN expression in endometrial carcinoma I-J]. Cancer Sci, 2008, 99(4): 706-710.
  • 5Jiang B H, Liu L Z. PI3K/PTEN signaling in angiogenesis and tumorigenesis[J]. Adv Cancer Res, 2009, 102(1) : 19-65.
  • 6Koul D, Shen R, Garyali A, et al. MMAC/PTEN tumor suppressor gene regulates vascular endothelial growth factor mediated angiogenesis in prostate cancer[J]. Int J Oncol, 2002,21 (3):469- 475.
  • 7Stambolic V, Tsao M S, Macpherson D, et al. High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in PTEN +/- micek[J].Cancer Res, 2000, 60(13); 3605-3611.
  • 8Winter J L, Stackhouse B L, Russell G B, et al. Measurement of PTEN expression using tissue microarrays to determine a race-specific prognostic marker in breast cancer[J].Arch Pathol Lab Med, 2007, 131(5):767 -772.
  • 9Depowski P L, Rosenthal S I, Ross J S. Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer[J].Mod Pathol, 2001, 14(7):672-776.
  • 10Lee J S, Kim H S, Kim Y B, et al, Reduced PTEN expression is associated with poor outcome and angiogenesis in invasive ductal carcinoma of the breast[J].Appl Immunohistochem Mol Morphol, 2004, 12(3):205 -210.

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肿瘤学杂志
2006年 第4期

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