摘要
目的:研究甘氨双唑钠(CMNa)的致畸性。方法:采用传统致畸学试验方法,检测了CMNa对Sprague-Dawley孕鼠在致畸敏感期的潜在毒性。试验设139.9,279.0和1399.0mg/kg3个剂量组(分别相当于1/20,1/10和1/2LD50),同时设对照组(生理盐水),采用尾静脉注射给药。结果:孕鼠接受CMNa后,母体体重减轻,并随剂量的增大而有剂量-效应关系。高剂量(1399.0mg/kg)组吸收胎增多,活胎率和平均每窝活胎数降低,并有一定程度的胎鼠畸形,总畸形率达9.4%。同时还显示CMNa在279.0mg/kg剂量时有母体毒性和胚胎毒性,但无致畸作用;在139.9mg/kg剂量时,仅有母体毒性而无胚胎毒性和致畸作用。结论:该药在临床推荐应用剂量下使用比较安全。
Objective: To study the teratogenesis of glycididazolum natrium. Methods: Conventional teratogical experiment in vivo with SD rats was carried out. The compound was injected into pregnant rats through tail veins at the dosage of 139. 9, 279. 0 and 1 399. 0 mg/kg(equal to 1/20, 1/10 and 1/2 LD50) respectively; at the same time, normal saline was used for the negative control group. Results: The body weights of pregnant rats reduced after injection, and the changes of body weight were dose-dependent(P<0. 05, P<0. 01 ). At the dosage of 1 399. 0 mg/kg, the numbers of absorbed fetal went up, the rates of live fetus and the mean numbers of live fetus per litter went down, with the fetal malformations, 9. 4% total malformation rates and embryo toxicities. It showed maternal and embryo toxicities and no malformation effects in the 279 mg/kg group, while it showed no embryo toxicities and malformation effects but maternal toxicites in 139. 9 mg/kg group. Conclusion: The drug will be safe if it is administered under the clinic dosage recommended.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1996年第3期210-212,共3页
Academic Journal of Second Military Medical University
基金
国家新药研究基金
关键词
甘氨双唑钠
母体毒性
胚胎毒性
致畸作用
glycididazolum natrium
maternal toxicities
embryo toxicities
malformation
rats