施维舒对大鼠急性胃粘膜损伤的防治作用

The preventive and treatment effects of selbex on acute gastric mucosal injury in rats

目的：观察施维舒对无水乙醇诱发大鼠急性胃粘膜损伤的防治作用。方法：将５６只ＳＤ大鼠分为正常对照（Ⅰ）、预防（Ⅱ）、治疗（Ⅲ）３个大组，再分预防对照（Ⅱａ）、施维舒预防（Ⅱｂ）、雷尼替丁预防（Ⅱｃ）、治疗对照（Ⅲａ）、施维舒治疗（Ⅲｂ）、雷尼替丁治疗（Ⅲｃ）等亚组。分别测定胃粘膜血流量（ＧＭＢＦ）、胃粘膜跨膜电位（ＰＤ）、损伤指数（ＵＩ）等多项指标。结果：Ⅱｂ、Ⅲｂ组与各自对照组比较发现，ＵＩ均显著降低（Ｐ＜０．０ｌ）；ＧＭＢＦ增加（Ｐ＜０．０１），其中Ⅲｂ组尚高于Ⅰ组（Ｐ＜０．０５）；ＰＤ升高（Ｐ＜０．０１）；胃粘膜氨基己糖、磷脂含量增加（Ｐ＜０．０１）；疏水性增强（Ｐ＜０．０１）。结论：施维舒是一种良好的胃粘膜细胞保护剂。

To observe the preventive and treatment effects of selbex on acute gastric mucosal injury induced by 100% ethanol in rats. Methods: Fifty-six SD rats were divided into 3 groups: normal group(Ⅰ) , preventive group(Ⅱ) including preventive control group(Ⅱa) , preventive group with selbex(Ⅱb) , preventive group with ranitidine(Ⅱc) and treatment group(Ⅲ) including treatment control group(Ⅲa) , treatment group with selbex(Ⅲb) , treatment group with ranitidine(Ⅱc ). Gastric mucosal blood flow(GMBF) , electrical potential difference across gastric mucosa(PD) , ulcer index(UI) and other indexes were measured, respectively. Results: In the selbex preventive and treatment groups compared with control groups: UI was significantly lower(P<0. 01), GMBF increased(P<0.01) , GMBF of group Ⅲ b higher than that of gorup Ⅱb(P <0.05) , PD elevated(P<0.05) , levels of hexosamine and phospholipid in the gastric mucosa were elevated(P<0.01), and surface hydrophobicity of the gastric mucosa was enhanced(P<0.01). Conclusion: Selbex is a beneficial cytoprotective agent of gastric mucosa.