摘要
观察尿激酶联合阿魏酸钠治疗Lee分级≥Ⅲ级的IgA肾病的临床疗效。入选的46例患者均经肾活检证实可确诊为IgA肾病(IgAN) , Lee分级≥Ⅲ级。将患者随机分为两组, A组: 单用阿魏酸钠; B组: 尿激酶(UK) 联合阿魏酸钠。结果表明, 两组患者治疗前后24 h尿蛋白、肌酐清除率等各项指标均得到不同程度改善, 而且尿激酶联合阿魏酸钠组的疗效更为明显。尿激酶联合阿魏酸钠治疗Lee分级≥III级的IgAN疗效优于单用阿魏酸钠, 并可改善患者的纤溶能力, 为一种安全有效的治疗方案。
To observe the effect of urokinese(uk) combined with sodium ferulate on IgA nephropathy (IgAN). 46 patients with IgAN were divided into two groups:group A, who were administrated with sodium ferulate; group B:who were administrated with sodium ferulate and urokinase. Both groups were received 6-month treatment. Two groups the quantitation of 24 hours proteinuria and serum creatinine change. But group B was significantly higher than that in group A. UK combined with sodium ferulate could be an effective and safe therapy on IgAN with moderate to advanced pathological changes.
出处
《科学技术与工程》
2006年第16期2532-2534,共3页
Science Technology and Engineering