大剂量丙种球蛋白治疗新生儿ABO溶血病的临床研究

The clinical study of ABO hemolytic disease of the newborn treated with numerous intravenous droping gammaglobulin

目的观察大剂量静脉滴注丙种球蛋白(IVIG)治疗新生儿ABO溶血病的临床效果。方法对符合新生儿ABO溶血病诊断标准且无其他合并症的51例患儿,分为常规治疗组和大剂量IVIG治疗组。IVIG治疗组在常规治疗的基础上给予IVIG1g·kg-·1d-1静脉滴注,每日1次,连续3日。结果IVIG治疗组在治疗前血清胆红素水平比较高的情况下,黄疸消退时间为4.18±1.03天,常规治疗组为5.28±1.50天,t=3.383,P<0.01。结论大剂量静脉滴注丙种球蛋白治疗新生儿ABO溶血病合并G6PD缺乏症临床疗效满意。

Objective To investigate the clinical effect of ABO hemolytic disease of the newborn treated with numerous intravenous droping gammaglobulin. Methods 51 cases with ABO hemolytic disease of the newborn without complication. They were divided into two groups ： the treatment group and the treatment of gammaglobulin group.The dosage of gammaglobulin 1g·kg^-1·d^-1, qd×3 days. Results The bilirubinemia regressive time was 4.18±1.03 days in the treatment of gammaglobulin group. The other group was 5.28±1.50 days, t=3.383, P〈0.01. Conclusion The numerous intravenous droping gammaglobulin was effective in ABO hemolytic disease of newborn.