盐酸纳洛酮治疗急性重型颅脑损伤昏迷的疗效观察

To observe the cure effect of early using Naloxone(Jin' Er Lun),for coma patients caused by acute severe brain injury

目的观察早期应用盐酸纳洛酮(金尔伦)对急性重型颅脑损伤昏迷的疗效。方法将急性重型颅脑损伤昏迷65例患者随机分成2组,纳洛酮治疗组34例,常规对照组31例,分别观察两组病人的觉醒时间、颅内压变化、GCS评分、临床症状、CT变化及远期效果。结果纳洛酮治疗组缩短昏迷时间,降低颅内压升高幅度,临床症状减轻,偏瘫、失语、致残、死亡率降低。结论早期使用大剂量纳洛酮明显降低急性重型颅脑损伤致残、死亡率,减轻脑水肿,促使脑神经功能恢复,改善生活质量。

Objective To observe the cure effect of early using Naloxone （jin＇ Er Lun） for coma patients caused by acute severe brain injury. Methods 65 patients with acute severe brain injury were randomized into two groups,the rivastigmine group of 34 cases took Naloxone therapy ,compared with a control group of 31 cases without Naloxone cure , to analyze the awaken time, intracranial pressure （ICP） alteration,GCS evaluation, CT change and reniote effect of the two groups individually. Results It can decrease the coma time ,lower the ICP ease the symptoms,and reduce the morbidity and mortality,in the Naloxone therapy group. Conclusion Early using high-dosed Naloxone for the acute severe brain injury can obviously lower the morbidity and mortality ,lighten the neurologic outcome and improve the live quality of the patients.