复方蛇舌草口服液对移植性动物肿瘤的影响

The influence of Compound Oldenlandia diffusal oral solution on transplanted animal tumor

目的考察复方蛇舌草口服液的抗肿瘤作用。方法采用S180肉瘤、H22肝癌作为实验瘤株,进行移植性动物肿瘤实验,观察复方蛇舌草口服液对S180肉瘤的抗瘤作用及对H22腹水型肝癌生存期的影响。结果复方蛇舌草口服液对小鼠S180移植性实体瘤有明显抑制作用,抑制率为34.46%,对H22腹水型肝癌小鼠的生存期无明显延长;其最大给药量为生药10.25.gkg-1;加用化学药5-氟尿嘧啶(5-FU)的增效试验显示,高、中剂量组抑制率分别为68.04%、52.40%。结论复方蛇舌草口服液具有一定的抗肿瘤作用,与化学药5-FU合用的增效作用不明显。

OBJECTIVE To observe the antitumor action of Compound Oldenlandia diffusal oral solution. METHODS S180 sarcom and H22 Hepatocarcinoma were used for the transplanted animal tumor. The influences of the antitumor action of S180 and the survival time of H22 treated with Compound Oldenlandia diffusal oral solution were observed,acute toxicity excperiment was taken and the MTD of the drug was detected. RESULTS Compound Olderdandia diffusal oral solution effecting on S180 transplanting tumor mouse had obvious action, the tumor inhibition rate of 34. 46%. While terms of survival time of H22 - beefing mouse. Its prolongation was not obvious. The MTD of the herb compound preparation was 10.25 g·kg^-1. The inhibition rate of high,middle dose group with 5 - FU was 68. 04% and 52.40% ,respectively. CONCLUSION Compound Olderdandia diffusal oral solution can inhibit the growth of tumor in vivo,and enhance the antitumor action target with 5 -FU.