补肾健脑汤治疗血管性痴呆的临床研究

Clinical Study on Effect of Bushenjiannao Decoction in Vascular Dementia Patients

目的探讨自拟补肾健脑汤对血管性痴呆(VD)病人的疗效及其对VD病人血液流变学、血脂及脑血流的影响。方法将72例VD病人随机分为治疗组与对照组。两组治疗前后均计算长谷痴呆量表(HDS)和简易精神状态检查表(MMSE)积分,测定血液流变学及血脂各项指标,TCD检测VD病人脑血流的变化。结果两组HDS和MMSE积分治疗后均较治疗前有明显提高(P<0.01);治疗组治疗后血液流变学及血脂各项指标均有明显改善(P<0.05),而对照组仅低切变率全血黏度有明显的降低作用(P<0.05);治疗组对血流速度减慢的VD病人的平均血流速度均有增加趋势,其中对大脑中动脉的血流速度显著增加(P<0.05)。结论补肾健脑汤可以明显提高VD病人的智能水平,其作用机制可能是通过降低血液黏度,调节脂代谢紊乱,增加脑血流量,改善脑循环而实现的。

Objective To observe the efficacy of Bushenjiannao decoction （BSJND） on vascular demelia（VD） patients. Methods Seventy - two VD patients were divided into two groups randomly, the 38 patients in the treated group were treated by BSJND orally and 34 patients in the control group were treated by Piracetam and Hydergine with a therapeutic course of three months for both groups. While before and after treatment, the HDS and MMSE score value was counted, hemorhealogy and blood- lipid were checked, cerebral blood fow was examinated with TCD. Results Both the HDS and MMSE score value were enhanced significatly in both groups after treatment （P 〈 0.01 ）, but both groups have not difference significatly （P 〉 0, 05）. The treatment group index of all Hemorheology and Blood- lipid were change significatlgy in after treatment（ P 〈 0,05）. The treatment group velocity of Blood flow on arteria cerebral media of patients by TCD were faster siagnificatly in after treatment （P 〈 0.05）. But, above- mentioned indexes on control group were not changed siagnificatly（ P 〉 0.05）, Conclusion BSJND could enhance intelligence level of patients with VD. The mechanism maybe is lower viscosity of blood , regulated blood - lipid metabolic disorder, enhanced cerebral blood flow, improve circulation.