星状神经节阻滞治疗Graves眼病的临床研究

Clinical study of stellate ganglion block in Graves ophthalmopathy

目的:评价星状神经节阻滞(SGB)治疗Graves眼病(GO)的疗效及安全性。方法:符合GO诊断标准患者42例,随机分两组,治疗组行SGB治疗,每日1次,对照组予皮质激素治疗,观察治疗后突眼度、眼部症状和体征改善以及各种抗体的变化情况。结果:SGB治疗后患者眼突度有明显改善,总有效率为85.7%(18/21),且疗效优于对照组(P<0.05);两组治疗前后眼部症状有明显缓解,甲状腺球蛋白抗体(TGAb)、甲状腺微粒体抗体(TmAb)、TSH受体抗体(TRAb)较治疗前有明显下降,差异非常显著(P<0.01)。结论:SGB能有效治疗GO,明显改善眼部症状。

Objective： To evaluate the efficacy and safety of stellate ganglion block（SGB） in treatment of Graves ophthalmopathy （GO）. Methods： 42 patients with GO were allocated randomly to treatment group on a basis of daily SGB and control group with cortisol for observing the change of exophthalmos, eye symptoms and thyroid antibodies. Results： Exophthalmos in treatment group were improved significantly. The overall effective rate was 85.7 % （18/21）. which was higher than that in the control group. Thyroglobulin antibodies （TGAb）, thyroid microsome antibodies （TmAb）and thyrotropin receptor antibodies （TRAb） were decreased significantly （ P 〈 0.01 ）. Conclusion ： SGB is an effective way to treat GO and can improve eye symptoms.