三康胶囊对高原人体运动一氧化氮及其合酶的影响

Effect of Sankang capsule on nitric oxide and nitric oxide synthase after load exercise at high altitude

目的:探讨三康胶囊对高原人体运动一氧化氮(NO)及其合酶(NOS)的影响。方法:对进驻海拔3 700 m高原1年的10名健康青年在服药前和服药第15天分别采用功率自行车进行渐增负荷运动,测定血清NO和NOS的含量。结果:服药前运动后NO及NOS分别为(77.10±8.11)μmol/L及(56.29±6.28)U/m l,服药后运动后NO及NOS分别为(101.02±6.49)μmol/L及(71.40±7.23)U/m l,两组间具有非常显著差异(P<0.01)。结论:三康胶囊能增强高原运动时NOS活性,NO合成增加,降低氧耗,提高机体免疫力。

Objective： To explore the effect of Sankang capsule on nitric oxide （NO） and nitric oxide synthase （NOS） of human being after load exercise at high altitude. Methods： Ten young soldiers stayed at high altitude of 3 700 m for 1 year underwent load exercise tests with the EGM bicycle ergometer. Activities of NO and NOS were measured before administration and after taking drug for 15 days. Results： The levels of NO and NOS before administration and after taking drug for 15 days were 77.10 ± 8.11 μmol/L vs 101.02 ±6.49 μmol/L （ P 〈 0.01） ,and 56.29 ±6.28 U/ml vs 71.40 ±7.23 U/ml （P 〈0.01）, respectively. Conclusion： Sankang capsule can improve NOS activity during load exercise at high altitude, increase synthesis of NO, reduce oxygen depletion, and enhance immune function.