膜联蛋白-1在膀胱移行细胞癌发生发展中的表达

Annexin Ⅰ expression in transitional cell carcinoma of bladder,atypical hyperplasia and normal bladder mucosa

目的:探讨AnnexinⅠ在膀胱移行细胞癌、不典型增生及正常膀胱移行上皮组织中的表达,为膀胱移行细胞癌的早期诊断、治疗提供实验和理论依据。方法:应用免疫组化SABC法检测67例膀胱移行细胞癌、22例不典型增生和10例正常膀胱移行上皮组织中AnnexinⅠ的表达。结果:膀胱移行细胞癌、不典型增生和正常膀胱移行上皮组织中AnnexinⅠ的表达率分别为29.85%、31.82%及100%。结论:AnnexinⅠ在正常膀胱移行上皮组织中呈强阳性表达,而在不典型增生及膀胱移行细胞癌中表达明显下降或丢失,提示与移行上皮癌变有关,有望作为膀胱移行细胞癌早期诊断的指标。

Objective：To study the expression level of Annexin Ⅰ in normal bladder mucosa, atypical hyperplasia and transitional cell carcinoma of bladder, and provide experimental and theoretical guide for the diagnosis and treatment of transitional cell carcinoma of bladder. Methods： Annexin Ⅰ expression was examined by immunohistochemieal SABC method in 10 normal bladder mueosa, 22 atypical hyperplasia and 67 transitional cell carcinoma of bladder tissues. Results： The positive rates of Annexin Ⅰ expression in normal bladder mueosa, atypical hyperplasia and transitional cell carcinoma of bladder were 100%, 31.82% and 29.85%, respectively. Conclusion：The results of strong Annexin Ⅰ expression in normal bladder mueosa and weak Annexin Ⅰ expression in the atypical hyperplasia and transitional cell carcinoma of bladder indicate that Annexin Ⅰ may play an important role in the development of early transitional cell carcinoma of bladder, and it could be a useful biological marker of early diagnosis of transitional cell carcinoma of bladder.