122株临床真菌及其耐药性分析

Analysis of 122 clinical fungi strains and their drug resistance

目的:了解医院深部真菌感染状况及其耐药性,为指导临床用药提供依据。方法:对2004年临床真菌感染标本进行回顾性分析。结果:122株深部真菌感染占医院感染的9.4%,其中以白色念珠菌(白色假丝酵母菌)为主。5-氟胞嘧啶、两性霉素-B、制霉菌素对真菌保持较高体外抗真菌活性,敏感率分别为91.8%、86.1%、70.8%;但咪康唑、酮康唑、益康唑耐药率较高,分别为80.8%、79.4%、72.6%,其中益康唑中介达19.2%。结论:我院真菌感染以白色念珠菌为主。5-氟胞嘧啶,两性霉素B,制霉菌素是目前我院治疗真菌感染的有效药物。唑类抗真菌药耐药率较高,采取有效干预措施刻不容缓。

Objective： To investigate the infection status of hospital deep fungus and its drug resistance, and provideimportant information for clinical diagnosis and therapy. Methods： Clinical data of 122 patients with fungus infection in 2004 were analyzed retrospectively. Results： Infection rate of deep fungus was 9.4%, and the incidence of candida albicans infection was 63.9%. The susceptibility rates of isolated fungus to 5 - fluorocytosine （5-FC）, amphotericin B （AMB） and nystatin （NYS） were 91.8%, 86.1% and 70.8%, respectively, and the drug resistant rates to miconazole （ MIZ）, ketoconazole （KET） and econazole （ECO） were 80.8%, 79.4% and 72.6%, respectively. The middle drug resistance rate to ECO was 19.2%. Conclusion： Candida albicans is still the essential strain in hospital fungus infection. 5 - FC, AMB and NYC are effective for treatment of fungus infection. Evident resistance can be found in some antifungal drugs, especially azoles. Some effective measures should be taken to control hospital fungus infection.