氟苯尼考对禽多杀性巴氏杆菌的抗菌后效应

Post-antibiotic Effect of Florfenicol against Pasteurella multocida(birds) in vitro

采用菌落计数法测定氟苯尼考对禽多杀性巴氏杆菌的体外抗菌药后效应（PAE）、抗菌后亚抑菌浓度效应（PA-SME）及亚抑菌浓度效应（SME）。结果显示：氟苯尼考在2～8MIC（μg／mL）范围内对禽多杀性巴氏杆菌的PAE为1．31～5．01h，PA-SME为1．66-24．20h，SME为0．05～1．31h；其PAE受药物浓度、细菌接触时间及接种量的影响。结果提示：临床应用氟苯尼考治疗禽多杀性巴氏杆菌病时，应结合药代动力学参数和MIC及PAE，制订给药方案。

The post-antibiotic effect （PAE）, the post-antibiotic sub-MIC effect （PA-SME） and sub- MIC effect （SME） of florfenicol （Ff） against Pasteurella multocida in vitro were determined in this study. Mueller-Hinton agar colony counting method was used to monitor the growth of bacteria. The results showed that PAEs of Ff against P. multocida at 2-8 × MIC were 1.31-5. 01 h, PA-SMEs 1.66-24. 2 h and SMEs 0. 05-1. 31 h. It was demonstrated that Ff against P. multocida was affected by the concentration of antimicrobial agents,the exposure time and the concentration of organism. This study suggested that the administration scheme of Ff against P. multocid should be considered to combine its pharmacokinetic parameters,MIC and PAE.