摘要
目的探讨用阿立哌唑替换传统和其他非典型抗精神病药物治疗的疗效、耐受性和安全性。方法对118例使用传统和其他非典型抗精神病药治疗的精神分裂症患者换用阿立哌唑治疗8周,用PANSS、CGI-GI、TESS作为评估工具,于换药前及换药后的第1、2、4、8周进行评分,然后对换药前后的疗效、耐受性和安全性进行比较。结果所有患者都顺利地从原来的药物换用了阿立哌唑治疗,换用阿立哌唑后PANSS总分、阴性症状以及CGI疾病严重程度均得到改善,P<0.05或P<0.01。嗜睡、EPS、体重增加、月经紊乱、静坐不能等副反应显著减少。结论阿立哌唑替换传统和其他非典型抗精神病药物,可以提高疗效,减少副反应,显示了良好的疗效、耐受性和安全性,有利于长期服药维持治疗。
Objective To explore the clinical efficacy , toleration and safety of aripiprazole replacing traditional antipsychotics and other atypical antipsychotics. Methods A total of 118 patients received treatment with aripiprazole for 8 weeks. The Positive and Negative Symptoms Scale(PANSS) , Clinical Global Impression(CGI) and Treatment Emergent Symptoms Scale(TESS) were used to evaluate the efficacy ,toleration and the safety before replacement and at the end of 1st, 2nd, 4th ,8th week. Results All patients successfully received aripiprazole replacing traditional antipsychotics and other atypical antipsychotics. After replacement, the total scores of PANSS , the scores of negative symptoms in PANSS and CGI significantly improved (P 〈 0.05 or P 〈 0.01). The incidence rate of the drowsiness, EPS , body weight gain , menstrual disorder , acathisia and other side effects significantly reduced. Conclusions The clinical efficacy, toleration and the safety of aripiprazole are batter than those of the traditional antipsychotics and other atypical antipsychotics. Aripiprazole is a new drug in treating schizophrenia with lower side effects and better effect for long-term treatment.
出处
《神经疾病与精神卫生》
2006年第4期274-276,共3页
Journal of Neuroscience and Mental Health