呼吸道合胞病毒感染及反义基因治疗的研究进展
被引量:2
摘要
一、呼吸道合胞病毒(respiratory syncytial virus,RSV)感染及治疗现状
1.RSV基因结构与蛋白功能:RSV属于副黏病毒科,肺炎病毒属,为非节段性单股负链RNA病毒,含有大约15000个核苷酸,其基因顺序依次为:3′NS1-NS2-N-P-M-SH-G-F-M2-(M2-1/M2-2)-L-5′,共编码11个病毒蛋白,分别为:
出处
《中华儿科杂志》
CAS
CSCD
北大核心
2006年第8期629-632,共4页
Chinese Journal of Pediatrics
基金
国家自然科学基金(30340045)
参考文献40
-
1Collins PL,Dickens LE,Buckler-White A,et al.Nucleotides sequence for the gene junction of human respiratory syncytial virus reveal the distinctive features of intergenic structure and gene order.Proc Natl Acad Sci USA,1986,83:4594-4598.
-
2Collins PL,Hill MG,Cristina J,et al.Transcription elongation factor of respiratory syncytial virus,a nonsegmented negative-strand RNA virus.Proc Natl Acad Sci USA,1996,93:81-85.
-
3Grosfeld H,Hill MG,Collins PL.RNA replication by respiratory syncystial virus (RSV) is directed by the N,P,and L proteins;transcription also occurs under these conditions but requires RSV superinfection for efficient synthesis of full-length mRNA.J Virol,1995,69:5677-5686.
-
4Bermingham A,Collins PL.The M2-2 protein of human respiratory syncystial virus is a regulatory factor involved in the balance between RNA replication and transcription and transcription.Proc Natl,1999,96:11259-11264.
-
5Prober CG,Sullender WM.Advancers in prevention of respiratory syncytial virus infections.J Pediater,1999,135:546-558.
-
6Whitehead SS,Bukreyev A,Teng MN,et al.Recombinant Respiratory Syncytial Virus Bearing a Deletion of either the NS2 or SH Gene Is Attenuated in Chimpanzees.J Virol,1999,73:3438-3442.
-
7陈慧中.呼吸道合胞病毒感染的防治[J].实用儿科临床杂志,2001,16(3):176-177. 被引量:47
-
8Maggon k,Barik S.New drugs and treatment for respiratory syncytial virus.Rev Med Virol,2004,14:149-168.
-
9Cramer H.Antisense approaches for inhibiting respiratory syncystial virus.Expert Opin Biol Ther,2005,5:207-220.
-
10Gern JE.Mechanisms of virus-induced asthma.J Pediatr,2003,142:9-13.
二级参考文献79
-
1Piedra PA. Respiratory syncytial virus vaccine: recent developments. Pediatr Infect Dis J. 2000. 19:805-808.
-
2Santoro SW, Joyce GF. A general purpose RNA-cleaving DNA enzyme. Pro Nat] Acad Sci USA. 1997.94:4262-4266.
-
3Player MR, Barnard DL, Torrence PF. Potent inhibition of respiratory syncytial virus replication using a2-SA-antisense chimera targeted to signals within the virus genomic RNA. Proc Natl Acad Sci USA, 1998, 95:8874-8879.
-
4Cirino NM, Li G, Xiao W, et al. Targeting RNA decay with 2',5'oligoadenylate-antissense in respiratory syncytial virus -infected cells.Proc Natl Acad Sci USA. 1997.94:1937-1942.
-
5Wu Y, Yu I, Mcmahon R, et al. Inhibition of bcr-abl oncogenr expression by novel deoxyribozyme. Hum Gene Ther, 1999, 10:2847 -2857.
-
6Finkle E. DNA cuts its teeth-as an enzyme. Science, 1999, 286:2441-2442.
-
7Lowe HC, Fahmy RG, Kavurma MM, et al. Catalytic oligodeoxynucleotides defme a key regulatory role for early growth response factor-1 in the porcine model of coronary in-stent restenosis.Circ Res , 2001,89:670-677.
-
8Sriram B, Baneljea AC. In vitro-selected RNA cleaving DNA enzymes from a combinatorial library are potent inhibitors of HIV-1 gene expression. Biochem J, 2000, 352( Pt 3) :667-673.
-
9Unwalla H, Banerjea AC. Inhibition of HIV-1 gene expression by novel macrophage-tropic DNA enzymes targeted to cleave HIV-1 TAT/Rev RNA. Biochem J, 2001, 357(Pt 1) :147-155.
-
10Toyoda T, Imamura y, Takaku H, et al. Inhibition of influenza virus replication in cultured cells by RNA-cleaving DNA enzyme.FEBS Lett, 2000, 481:113-116.
共引文献64
-
1刘玉霞,胡静,王庆九.炎琥宁联合α-细辛脑治疗毛细支气管炎临床疗效观察[J].中国实用医药,2006,1(4). 被引量:4
-
2伊正君,朱道银.病毒学研究的新工具:脱氧核酶及其应用[J].国外医学(病毒学分册),2004,11(3):69-72. 被引量:1
-
3蒋惠娟,卢秋穗,张银美,周艳,邵小松.婴儿急性下呼吸道感染与呼吸道合胞病毒、巨细胞病毒、肺炎支原体的关系[J].实用儿科临床杂志,2004,19(8):672-673. 被引量:4
-
4傅红.普米克令舒联合博利康尼令舒治疗毛细支气管炎疗效观察[J].实用药物与临床,2004,7(4):84-84. 被引量:2
-
5蔡东黎.布地奈德吸入与地塞米松静滴治疗小儿毛细支气管炎疗效的对照观察[J].现代实用医学,2004,16(11):664-665.
-
6李亚杰,刘文静,宋杨.布地奈德泵吸治疗毛细支气管炎疗效观察[J].黑龙江医药科学,2005,28(1):45-45. 被引量:1
-
7李凤启.炎琥宁注射液治疗小儿病毒性肺炎25例[J].中国基层医药,2005,12(3):372-372. 被引量:2
-
8方学平,梅兴国,龚伟.硫酸卡那霉素体外抑制呼吸道合胞病毒作用的研究[J].中国抗生素杂志,2005,30(4):247-249. 被引量:2
-
9朱丽芳,吴雅玲.普米克、喘康速气雾剂联合吸入治疗毛细支气管炎50例疗效观察[J].中原医刊,2005,32(9):48-48.
-
10刘引,王子才,徐昀,胡润芳,袁芳,夏慧芬.上海西南地区儿童肺炎非细菌病原研究[J].实用儿科临床杂志,2005,20(8):769-770. 被引量:1
同被引文献27
-
1林立,李昌崇.呼吸道合胞病毒感染发病机制[J].中华儿科杂志,2006,44(9):673-675. 被引量:45
-
2徐霞,隋在云,隋丽云.金贝清肺颗粒体内抗呼吸道合胞病毒作用的实验研究[J].时珍国医国药,2007,18(2):403-404. 被引量:7
-
3Fattouh AM, Mansi YA, Elanany MG, et al. Acute lower respiratory tract infection due to respiratory syncytial virus in a group of egyptian children under 5 years Of age [J]. Ital J Pediatr,2011,37(1):14.
-
4Schiller O, Levy I, Pollak U, et al. Central apnoeas in infants with bronchiolitis admitted to the paediatrie intensive care unit [J]. Acta Paediatr,2011,100(2):216-219.
-
5Akiyama N, Segawa T, Ida H, et al. Bimodal effects of obesity ratio on disease duration of respiratory syncytial virus infection in children [M]. Allergol Int,2011.
-
6Bertrand P, Aranibar H, Castro E, et al. Efficacy of nebulized epinephrine versus salbutamol in hospitalized infants with bronchio- olitis [J]. Pediatric Pulmonol,2003,360(9327): 101-102.
-
7Cade Brownlee KG, Corrway SP, et al. Randomised placebo-contr- olled trial of nebulised corticostrolitis in acute respiratory syneytial viral bronchiolitia [J]. Arch Dis Child,2000,82:126-130.
-
8H. Cody Meissner, MD, Sarah S. Long. Revised indications for the use of palivizumab and respiratory syncytial virus immune globulin intravenous for the prevention of respiratory syncytial virus infections. [J]. Pediatrics,2003,112(6): 1442-1446.
-
9Duma MC, Knight DA, Waldman WJ. Inhibition of respiratory syncytial virus in vitro and in vivo by the immunosuppressive agent leflunomide [J]. Antivir Ther,2011,16(3):309-317.
-
10Groothuis JR, Hoopes JM, Hemming VG. Prevention of serious respiratory syncytial virus-related illness. II: Immunoprophylaxis [J]. Adv Ther.,2011,28(2): 110-125.
二级引证文献4
-
1鲁靖,殷菊,李云娟,王雷.新生儿呼吸道合胞病毒下呼吸道感染临床分析及随访[J].中华实用儿科临床杂志,2014,29(6):436-439. 被引量:15
-
2孙淑媛,曹从品,李博,李华,韩彩丽,刘桂玲.儿童流行性感冒病毒及呼吸道合胞病毒感染特征分析[J].中国妇幼保健,2015,30(32):5572-5574. 被引量:14
-
3龙苏,袁媛,禹文峰,杨国辉,刘晓娴.甜橙黄酮通过调节AMPK/mTOR信号通路改善呼吸道合胞病毒感染大鼠的肺组织损伤[J].现代生物医学进展,2023,23(8):1424-1429.
-
4刘莎,宋文秀.毛细支气管炎的治疗进展[J].医学综述,2019,0(12):2422-2426. 被引量:17
-
1王之樑.小儿肺炎的几个临床问题 小儿肺炎病毒病原诊断方法及其选择[J].中国实用儿科杂志,2000,15(10):583-584. 被引量:5
-
2李艮亮,华杰.婴幼儿支气管肺炎病毒病原学检测[J].中国农村医学杂志,2006,4(4):33-33.
-
3刘兰青,陈淑荣,刘庆,魏克伦,杨玉坤.新生儿肺炎病毒病原学研究[J].中国医科大学学报,1995,24(3):287-288. 被引量:4
-
4副黏病毒[J].健康人,2003(5):25-25.
-
5陆东东.原发性肝癌相关基因[J].医学研究杂志,1998,32(6):7-10. 被引量:3
-
6自体和异体基因顺序移植治疗骨髓瘤[J].家庭医学(上半月),2009(2):59-59.
-
7陈杭薇,邬光惠,周景,李继成,尤兰华,刘晓联.肺癌K-ras基因突变与呼吸道合胞病毒感染关系的研究[J].第三军医大学学报,2001,23(7):830-832. 被引量:9
-
8陈杭薇,邬光惠,周景,李继成,尤兰华,刘晓联.肺癌呼吸道合胞病毒感染与K-ras基因突变的研究[J].诊断病理学杂志,2000,7(1):50-50. 被引量:1
-
9刘开扬,刘芳.新城疫病毒抗癌作用及其应用的研究进展[J].中国肿瘤生物治疗杂志,2002,9(4):289-291. 被引量:2
-
10张拓慧,赵林清.呼吸道合胞病毒感染中细胞因子的作用研究[J].国际病毒学杂志,2017,24(1):65-69. 被引量:1